RT Journal Article
T1 Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
A1 Izquierdo Barba, Isabel
A1 García Martín, José Miguel
A1 Álvarez, Rafael
A1 Palmero, Alberto
A1 Esteban, Jaime
A1 Pérez-Jorge Peremarch, María de la Concepción
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
AB Bacterial colonization and biofilm formation on orthopedic implants is one of the worst scenarios in orthopedic surgery, in terms of both patient prognosis and healthcare costs. Tailoring the surfaces of implants at the nanoscale to actively promote bone bonding while avoiding bacterial colonization represents an interesting challenge to achieving better clinical outcomes. Herein, a Ti6Al4V alloy of medical grade has been coated with Ti nanostructures employing the glancing angle deposition technique by magnetron sputtering. The resulting surfaces have a high density of nanocolumnar structures, which exhibit strongly impaired bacterial adhesion that inhibits biofilm formation, while osteoblasts exhibit good cell response with similar behavior to the initial substrates. These results are discussed on the basis of a ‘‘lotus leaf effect’’ induced by the surface nanostructures and the different sizes and biological characteristics of osteoblasts and Staphylococcus aureus.
PB Elsevier
SN 1742-7061
YR 2015
FD 2015-03-15
LK https://hdl.handle.net/20.500.14352/24049
UL https://hdl.handle.net/20.500.14352/24049
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Agening Network of Excellence
NO Ministerio de Ciencia y Competitividad (MINECO)
NO Junta de Andalucía
DS Docta Complutense
RD 8 abr 2025