RT Journal Article T1 Basic Assessment of Paced Activation Sequence Mapping: Implications for Practical Use A1 Pérez Castellano, Nicasio A1 Almendral Garrote, Jesús A1 Pérez Villacastín Domínguez, Julián A1 Arenal, Ángel A1 Gonzalez, Sergio A1 Moreno, Javier A1 Morales, Ricardo A1 Macaya Miguel, Carlos AB Some experiences support the use of atrial paced activation sequence mapping, but there is no systematic study assessing its spatial resolution, reproducibility, and influence of pacing parameters. The aim of this study was to evaluate these issues by using a 24-pole catheter positioned at the atrial aspect of the tricuspid and mitral annuli in 15 patients. Bipolar pacing was performed at two sites (right and left atria), 2 cycle lengths (300 and 500 ms) and two outputs (twice and tenfold the late diastolic threshold voltage for 2-ms pulses). The elapsed time between the atrial activation at the two dipoles adjacent to the pacing dipole (activation time [AT]) was measured during each pacing sequence. Changes in cycle length did not modify the AT. The increase in voltage slightly modified the AT (maximum -2 ms at the RA; 95% CI -3 to -1 ms) due to a greater shortening of the conduction time to the dipole located next to the anode. The 95% limits of the intraobserver and interobserver agreements in the AT measurement were -2 to 3 ms and -3 to 3 ms, respectively. The spatial resolution was studied in ten patients by measuring the AT during pacing from each dipole of a 20-pole catheter with a 1-3-1 mm interelectrode distance. The mean AT change was 10 +/- 4 ms per 6 mm of pacing site displacement (95% CI 8-11 ms, range 2.5-20 ms). In conclusion, paced atrial activation sequence analysis is reproducible, accurate, and relatively independent of pacing parameters. PB Wiley SN 0147-8389 YR 2004 FD 2004-05 LK https://hdl.handle.net/20.500.14352/114668 UL https://hdl.handle.net/20.500.14352/114668 LA eng NO Perez-Castellano N, Almendral J, Villacastin J, Arenal A, Gonzalez S, Moreno J, Morales R, Macaya C. Basic assessment of paced activation sequence mapping: implications for practical use. Pacing Clin Electrophysiol. 2004 May;27(5):651-6. doi: 10.1111/j.1540-8159.2004.00501.x. DS Docta Complutense RD 14 dic 2025