RT Journal Article
T1 A highly fluorescent and readily accessible all-organic photosensitizer model for advancing image-guided cancer PDT
A1 Garcia Sampedro, Andrés
A1 Prieto Castañeda, Alejandro
A1 Rodríguez Agarrabeitia, Antonia
A1 Bañuelos Prieto, Jorge
A1 García Moreno, Inmaculada
A1 Villanueva Oroquieta, Ángeles
A1 Moya Cerero, Santiago de la
A1 Ortiz García, María Josefa
A1 Acedo Núñez, Pilar
AB The potential of using image-guided photodynamic therapy (ig-PDT) for cancer, especially with highly biocompatible fluorescent agents free of heavy atoms, is well recognized. This is due to key advantages related to minimizing adverse side effects associated with standard cancer chemotherapy. However, this theragnostic approach is strongly limited by the lack of synthetically-accessible and easily-modulable chemical scaffolds, enabling the rapid design and construction of advanced agents for clinical ig-PDT. In fact, there are still very few ig-PDT agents clinically approved. Herein we report a readily accessible, easy-tunable and highly fluorescent all-organic small photosensitizer, as a model design for accelerating the development and translation of advanced ig-PDT agents for cancer. This scaffold is based on BODIPY, which assures high fluorescence, accessibility, and ease of performance adaptation by workable chemistry. The optimal PDT performance of this BODIPY dye, tested in highly resistant pancreatic cancer cells, despite its high fluorescent behavior, maintained even after fixation and cancer cell death, is based on its selective accumulation in mitochondria. This induces apoptosis upon illumination, as evidenced by proteomic studies and flow cytometry. All these characteristics make the reported BODIPY-based fluorescent photosensitizer a valuable model for the rapid development of ig-PDT agents for clinical use.
PB Royal Society of Chemistry
SN 2050-750X
YR 2024
FD 2024-07-12
LK https://hdl.handle.net/20.500.14352/114880
UL https://hdl.handle.net/20.500.14352/114880
LA eng
NO Garcia-Sampedro, A., Prieto-Castañeda, A., Agarrabeitia, A. R., Bañuelos, J., García-Moreno, I., Villanueva, A., de la Moya, S., Ortiz, M. J., & Acedo, P. (2024). A highly fluorescent and readily accessible all-organic photosensitizer model for advancing image-guided cancer PDT. Journal of Materials Chemistry B, 12(31), 7618-7625. https://doi.org/10.1039/D4TB00385C
NO Submitted: 23 Feb 2024; Accepted: 01 Jul 2024; First published: 12 Jul 2024.Authors acknowledge grants PID2020-114755GB-C31, -C32 and -C33 funded by Spanish MCIN/AEI/10.13039/501100011033, and grant IT1639-22 funded by Basque Government. A. P.-C. thanks grant FJC2021-046650-I funded by MCIN/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR. P. A. thanks funding from Pancreatic Cancer UK and the Ramon Areces Foundation.
NO Ministerio de Ciencia e Innovación (España)
NO Gobierno del País Vasco
NO European Union
NO Pancreatic Cancer UK
NO Ramon Areces Foundation
DS Docta Complutense
RD 6 abr 2025