RT Journal Article
T1 Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers
A1 Blanco‐Ramos, Javier
A1 Antón Toro, Luis Fernando
A1 Cadaveira, Fernando
A1 Doallo, Sonia
A1 Suárez‐Suárez, Samuel
A1 Rodríguez Holguín, Socorro
AB Binge drinking is a pattern of intermittent excessive alcohol consumption that is highly prevalent in young people. Neurocognitive dual-process models have described substance abuse and adolescence risk behaviours as the result of an imbalance between an overactivated affective-automatic system (related to motivational processing) and damaged and/or immature reflective system (related to cognitive control abilities). Previous studies have evaluated the reflective system of binge drinkers (BDs) through neutral response inhibition tasks and have reported anomalies in theta (4–8 Hz) and beta (12–30 Hz) bands. The present study aimed to investigate the influence of the motivational value of alcohol-related stimuli on brain functional networks devoted to response inhibition in young BDs. Sixty eight BDs and 78 control participants performed a beverage Go/NoGo task while undergoing electrophysiological recording. Whole cortical brain functional connectivity (FC) was evaluated during successful response inhibition trials (NoGo). BDs exhibited fast-beta and theta hyperconnectivity in regions related to cognitive control. These responses were modulated differently depending on the motivational content of the stimuli. The increased salience of alcohol-related stimuli may lead to overactivation of the affective-automatic system in BDs, and compensatory neural resources of the reflective system will thus be required during response inhibition. In BDs, inhibition of the response to alcohol stimuli may require higher theta FC to facilitate integration of information related to the task goal (withholding a response), while during inhibition of the response to no-alcoholic stimuli, higher fast-beta FC would allow to apply top-down inhibitory control of the information related to the prepotent response.
PB Wiley published on behalf of the Society for the Study of Addiction
SN 1355-6215
YR 2022
FD 2022-02-01
LK https://hdl.handle.net/20.500.14352/115865
UL https://hdl.handle.net/20.500.14352/115865
LA eng
NO Blanco‐Ramos, J., Antón‐Toro, L. F., Cadaveira, F., Doallo, S., Suárez‐Suárez, S., & Rodríguez Holguín, S. (2022). Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers. Addiction Biology, 27(2), e13141. https://doi.org/10.1111/adb.13141
NO Ministerio de Ciencia e Innovación (España)
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Educación, Cultura y Deporte (España)
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 10 abr 2025