RT Journal Article
T1 Olfactory epithelium influences the orientation of mitral cell dendrites during development
A1 López Mascaraque, Laura
A1 García García, María Concepción
A1 Blanchart, Albert
A1 De Carlos, Juan A.
AB We have established previously that, although the olfactory epithelium is absent in the homozygous Pax-6 mutant mouse, an olfactory bulb-like structure (OBLS) does develop. Moreover, this OBLS contains cells that correspond to mitral cells, the primary projection neurons in the olfactory bulb. The current study aimed to address whether the dendrites of mitral cells in the olfactory bulb or in the OBLS mitral-like cells, exhibit a change in orientation in the presence of the olfactory epithelium. The underlying hypothesis is that the olfactory epithelium imparts a trophic signal on mitral and mitral-like cell that influences the growth of their primary dendrites, orientating them toward the surface of the olfactory bulb. Hence, we cultured hemibrains from wild-type and Pax 6 mutant mice from two different embryonic stages (embryonic days 14 and 15) either alone or in coculture with normal olfactory epithelial explants or control tissue (cerebellum). Our results indicate that the final dendritic orientation of mitral and mitral-like cells is directly influenced both by age and indeed by the presence of the olfactory epithelium.
PB Wiley
SN 1058-8388
SN 1097-0177
YR 2004
FD 2004-12-21
LK https://hdl.handle.net/20.500.14352/131082
UL https://hdl.handle.net/20.500.14352/131082
LA eng
NO López-Mascaraque, L., García, C., Blanchart, A., & De Carlos, J. A. (2005). Olfactory epithelium influences the orientation of mitral cell dendrites during development. Developmental dynamics : an official publication of the American Association of Anatomists, 232(2), 325–335. https://doi.org/10.1002/dvdy.20239
NO Ministerio de Ciencia y Tecnologia (España)
DS Docta Complutense
RD 9 jun 2026