RT Journal Article
T1 Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets
A1 Simancas Herbada, Rebeca
A1 Fernández Carballido, Ana María
A1 Aparicio Blanco, Juan
A1 Slowing Barillas, Karla Verónica
A1 Rubio Retama, Benito Jorge
A1 López Cabarcos, Enrique
A1 Torres Suárez, Ana Isabel
AB The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two di_erent crosslinking degrees that were characterized by FTIR and DSC. Their acute oral toxicity was determined in a mouse model, showing no toxicity at doses up to 10 g/kg. Matrix tablets were prepared using metformin hydrochloride as a model drug and the mechanisms involved in drug release (swelling and/or erosion) were investigated using biorrelevant media. This new hydrogel e_ectively controlled the release of small and highly hydrophilic molecules as metformin, when formulated in matrix tablets for oral administration.The rate of metformin release from PAMgA matrices was mainly controlled by its di_usion through the gel layer (Fickian di_usion). The swelling capacity and the erosion of the matrix tablets influenced the metformin release rate, that was slower at pH 6.8, where polymer swelling is more intensive, than in gastric medium, where matrix erosion is slightly more rapid. The crosslinking degree of the polymer significantly influenced its swelling capacity in acid pH, where swelling is moderate, but not in intestinal fluid, where swelling is more intense.
PB MDPI
SN 1999-4923
YR 2020
FD 2020-02-19
LK https://hdl.handle.net/20.500.14352/6756
UL https://hdl.handle.net/20.500.14352/6756
LA eng
NO Simancas Herbada, R., Fernández Carballido, A. M., Aparicio Blanco, J. et al. «Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets». Pharmaceutics, vol. 12, n.o 2, febrero de 2020, p. 174. DOI.org (Crossref), https://doi.org/10.3390/pharmaceutics12020174.
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 10 abr 2025