RT Journal Article
T1 Different patterns of pulmonary vascular disease induced by type 1 diabetes and moderate hypoxia in rats
A1 Moral Sanz, Javier
A1 Lopez Lopez, José G.
A1 Menendez, Carmen
A1 Moreno González, Enrique
A1 Barreira, Bianca
A1 Morales Cano, Daniel
A1 Escolano, Lucia
A1 Fernandez Segoviano, Pilar
A1 Villamor, Eduardo
A1 Cogolludo Torralba, Ángel Luis
A1 Pérez Vizcaíno, Francisco
A1 Moreno Gutiérrez, Laura
AB Although type 1 and type 2 diabetes are strongly associated with systemic cardiovascular morbidity, the relationship with pulmonary vascular disease had been almost disregarded until recent epidemiological data revealed that diabetes might be a risk factor for pulmonary hypertension. Recent experimental studies suggest that diabetes induces changes in lung function insufficient to elevate pulmonary pressure. The aim of this study was to assess the effects of diabetes on the sensitivity to other risk factors for pulmonary hypertension. We therefore analysed the effects of the combination of diabetes with exposure to moderate hypoxia on classical markers of pulmonary hypertension. Control (saline-treated) and diabetic (70 mg kg-1 streptozotocin-treated) male Wistar-Kyoto rats were followed for 4 weeks and exposed to normoxia or moderate normobaric hypoxia (14%) for another 2 weeks. Hypoxia, but not diabetes, strongly reduced voltage-gated potassium currents, whereas diabetes, but not hypoxia, induced pulmonary artery endothelial dysfunction. Both factors independently induced pulmonary vascular remodelling and downregulated the lung bone morphogenetic protein receptor type 2. However, diabetes, but not hypoxia, induced pulmonary infiltration of macrophages, which was markedly increased when both factors were combined. Diabetes plus hypoxia induced a modest increase in diastolic and mean pulmonary artery pressure and right ventricular weight, while each of the two factors alone had no significant effect. The pattern of changes in markers of pulmonary hypertension was different for moderate hypoxia and diabetes, with no synergic effect except for macrophage recruitment, and the combination of both factors was required to induce a moderate elevation in pulmonary arterial pressure.
SN 0958-0670
SN 1469-445X
YR 2012
FD 2012-03-21
LK https://hdl.handle.net/20.500.14352/96905
UL https://hdl.handle.net/20.500.14352/96905
LA eng
DS Docta Complutense
RD 6 oct 2024