%0 Journal Article
%A Zhang, Meili
%A Wen, Bernard
%A Antón Hurtado, Olga María
%A Yao, Zhengsheng
%A Dubois, Sigrid
%A Ju, Wei
%A Sato, Noriko
%A DiLillo, David 
%A Bamford, Richard 
%A Ravetch, Jeffrey 
%A Waldmann, Thomas 
%T IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages
%D 2018
%@ 0027-8424
%U https://hdl.handle.net/20.500.14352/97029
%X Previously we demonstrated that IL-15 by continuous infusion at 2 μg/kg/d for 10 days induced a 38-fold increase in circulating natural killer (NK) cells and a 358-fold increase in CD56 bright NK cells. In the present study we demonstrated that IL-15 enhanced antibody-dependent cellular cytotoxicity (ADCC) of tumor-directed monoclonal antibodies in two systems. Both NK cells and macrophages were required for optimal therapeutic responses. These studies support clinical trials of IL-15 combined with tumor-directed monoclonal antibodies. In translation of this study, a phase I trial of IL-15 combined with alemtuzumab has been opened for patients with adult T cell leukemia (ATL) NCT02689453.
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