RT Journal Article
T1 The Interaction between Mitochondrial Oxidative Stress and Gut Microbiota in the Cardiometabolic Consequences in Diet-Induced Obese Rats
A1 Ortega Hernández, Adriana
A1 Martínez Martínez, Ernesto
A1 García Gordo, Rubén
A1 López Anfrés, Natalia
A1 Fernández Celis, Amaya
A1 Gutierrez Miranda, Beatriz
A1 Nieto, María Luisa
A1 Alarcón, Teresa
A1 Alba, Claudio
A1 Gómez Garre, Dulcenombre
A1 Cachofeiro Ramos, María Victoria
AB The objective of this study is to determine the role of mitochondrial oxidative stress in the dysbiosis associated with a high fat diet in rats. In addition, the impact of gut microbiota (GM) in the cardiometabolic consequences of diet-induced obesity in rats has been evaluated. Methods: Male Wistar rats were fed either a high fat diet (HFD) or a control (CT) one for 6 weeks. At the third week, one-half of the animals of each group were treated with the mitochondrial antioxidant MitoTempo (MT; 0.7 mgKg−1day−1 i.p). Results: Animals fed an HFD showed a lower microbiota evenness and diversity in comparison to CT rats. This dysbiosis is characterized by a decrease in Firmicutes/Bacteroidetes ratio and relevant changes at family and genera compared with the CT group. This was accompanied by a reduction in colonic mucin-secreting goblet cells. These changes were reversed by MT treatment. The abundance of certain genera could also be relevant in the metabolic consequences of obesity, as well as in the occurrence of cardiac fibrosis associated with obesity. Conclusions: These results support an interaction between GM and mitochondrial oxidative stress and its relation with development of cardiac fibrosis, suggesting new approaches in the management of obesity-related cardiometabolic consequences.
PB MDPI
YR 2020
FD 2020-07-21
LK https://hdl.handle.net/20.500.14352/112849
UL https://hdl.handle.net/20.500.14352/112849
LA eng
NO Ortega-Hernández A, Martínez-Martínez E, Gómez-Gordo R, López-Andrés N, Fernández-Celis A, Gutiérrrez-Miranda B, Nieto ML, Alarcón T, Alba C, Gómez-Garre D, Cachofeiro V.  Interaction between Mitochondrial Oxidative Stress and Gut Microbiota in the Cardiometabolic Consequences in Diet-Induced Obese Rats.Antioxidants (Basel). 2020 Jul 21;9(7):640. doi: 10.3390/antiox9070640.
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad
NO Comunidad de Madrid
DS Docta Complutense
RD 22 ene 2026