RT Journal Article
T1 Stress-induced takotsubo syndrome: dynamic changes in regional cerebral metabolism revealed by quantitative PET imaging
A1 Ariza Carrasco, Alejandro
A1 Yoganathan, Thulaciga
A1 Leciñana, María Alonso de
A1 Viel, Thomas
A1 Mikail, Nidaa
A1 López Herraiz, Joaquín
A1 Udías Moinelo, José Manuel
A1 Ibáñez García, Paula Beatriz
A1 Tavitian, Bertrand
A1 Pérez-Liva, Mailyn
AB Stress significantly contributes to cardiovascular diseases such as Takotsubo syndrome (TTS), which mimics an acute coronary syndrome without coronary obstruction. TTS is triggered by surgery, trauma, and emergency treatments in patients, and is reproduced in animal models by a catecholamine surge that impacts cardiac sympathetic innervation. The action of catecholamines on energy metabolism is well documented in the heart, less so in the brain. We investigated the effects of acute catecholaminergic stress on regional cerebral glucose metabolism and interregional metabolic organization in a TTS rat model using FDG-PET and quantitative two- tissue compartment modeling. Adult female rats received a single intraperitoneal injection of isoprenaline (ISO) (50 mg/kg). Dynamic FDG-PET imaging was performed at baseline, 2 hours (acute phase), and 7 days (recovery phase) post-injection. Kinetic parameters, namely glucose inflow (K1) and glucose phosphorylation (k3), were quantified in 58 brain regions. Interregional metabolic coordination, defined as statistically significant linear correlations between regional kinetic parameters, was assessed across functional brain areas. During the acute phase, the catecholaminergic surge induced widespread reductions in glucose inflow and regional decreases in phosphorylation, particularly in the limbic and sensorimotor areas. During the recovery phase, most regions remained below baseline. Metabolic coordination increased for glucose inflow in both phases but declined for phosphorylation, especially during recovery, indicating a disruption of metabolic synchronization. Persistent changes in brain metabolism imply that mid-to-long-term changes in regional cerebral metabolism may contribute to long-term TTS consequences.
PB Elsevier
SN 1053-8119
YR 2026
FD 2026-03
LK https://hdl.handle.net/20.500.14352/134175
UL https://hdl.handle.net/20.500.14352/134175
LA eng
NO Ariza-Carrasco, A., Yoganathan, T., De Leciñana, M.A., Viel, T., Mikail, N., Herraiz, J.L., Udias, J.M., Ibáñez, P., Tavitian, B., Pérez-Liva, M., 2026. Stress-induced takotsubo syndrome: dynamic changes in regional cerebral metabolism revealed by quantitative PET imaging. NeuroImage 328, 121797. https://doi.org/10.1016/j.neuroimage.2026.121797
NO © 2026 The Author(s).RYC2021-032739-I
NO European Commission
NO Universidad Complutense de Madrid
NO Ministerio de Ciencia e Innovación (España)
NO Agencia Estatal de Investigación (España)
NO Comunidad de Madrid
NO Institut National du Cancer (France)
NO Agence Nationale de la Recherche (France)
DS Docta Complutense
RD 9 abr 2026