RT Journal Article
T1 Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol
A1 Arévalo, María Ángeles
A1 Azcoitia Elías, Iñigo
A1 González Burgos, Ignacio
A1 García Segura, Luis Miguel
AB Estradiol participates in the regulation of the function and plasticity of synaptic circuits in key cognitive brain regions, such as the prefrontal cortex and the hippocampus. The mechanisms elicited by estradiol are mediated by the regulation of transcriptional activity by nuclear estrogen receptors and by intracellular signaling cascades activated by estrogen receptors associated with the plasma membrane. In addition, the mechanisms include the interaction of estradiol with the signaling of other factors involved in the regulation of cognition, such as brain derived neurotrophic factor, insulin-like growth factor-1 and Wnt. Modifications in these signaling pathways by aging or by a long-lasting ovarian hormone deprivation after menopause may impair the enhancing effects of estradiol on synaptic plasticity and cognition.
PB Science Direct
SN 0018-506X
YR 2015
FD 2015-08
LK https://hdl.handle.net/20.500.14352/23209
UL https://hdl.handle.net/20.500.14352/23209
LA eng
NO Ministerio de Economía y Competividad (MINECO)
DS Docta Complutense
RD 7 abr 2025