RT Journal Article
T1 Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms
A1 Xu, Xiaoqing
A1 Yu, Yixin
A1 Ling, Min
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Maximiliano Guerra, Jorge Enrique
A1 Martínez Larrañaga, María Rosa
A1 Wang, Xu
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
AB Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide and the most powerful pyrethroid insecticide in the world. However, there is increasing evidence that lambda-cyhalothrin is closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity and reproductive toxicity, among others) in non-target organisms, and oxidative stress seems to be the main mechanism of toxicity. This manuscript reviews the oxidative and mitochondrial damage induced by lambda-cyhalothrin and the signalling pathways involved in this process, indicating that oxidative stress occupies an important position in lambda-cyhalothrin toxicity. The mechanism of antioxidants to alleviate the toxicity of lambda-cyhalothrin is also discussed. In addition, the metabolites of lambda-cyhalothrin and the major metabolic enzymes involved in metabolic reactions are summarized. This review article reveals a key mechanism of lambda-cyhalothrin toxicity-oxidative damage and suggests that the use of antioxidants seems to be an effective method for preventing toxicity.
PB Elsevier
SN 0269-7491
YR 2023
FD 2023-10-03
LK https://hdl.handle.net/20.500.14352/102753
UL https://hdl.handle.net/20.500.14352/102753
LA eng
NO Xu, X., Yu, Y., Ling, M., Ares, I., Martínez, M., Lopez-Torres, B., ... & Martínez, M. A. (2023). Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms. Environmental Pollution, 122694.
NO Credit author statement: Xiaoqing Xu, Yixin Yu, Min Ling, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, Jorge-Enrique Maximiliano, María-Rosa MartínezLarranaga: ˜ Conceptualization, Methodology, Investigation, Data curation, Writing - original draft, Visualization. Xu Wang, Arturo Anadon and María-Aranzazu ´ Martínez: Conceptualization, Supervision, Writing – original draft, Writing – review & editing, Project administration. All authors have approved the final version of this manuscript.
DS Docta Complutense
RD 18 abr 2025