RT Journal Article
T1 Detection and molecular characterization of chicken parvovirus and chicken megrivirus in layer breeders affected by intestinal dilatation syndrome
A1 Nuñez Naranjo, Luis Fabian
A1 Chacón, Ruy D.
A1 Charlys Da Costa, Antonio
A1 Santander Parra, Silvana H.
A1 Da Costa Pereira Innocentini, Rafael
A1 Sánchez Llatas, Christian J.
A1 Cea Callejo, Pablo
A1 Valdeiglesias Ichillumpa, Stefhany
A1 Astolfi Ferreira, Claudete S.
A1 Marques de Sá, Lilian Rose
A1 Piantino Ferreira, Antonio J.
AB Intestinal dilatation syndrome (IDS) is a segmental enteropathy characterized by dilatation of the junction of the ileum and jejunum (Meckel’s diverticulum). IDS severely affects the poultry industry by causing a chronic and irreversible drop in egg laying, reducing feed conversion efficiency, and increasing the mortality rate. The clinical and pathological features of IDS in white laying hens were described, and viral molecular and metagenomic research was conducted. The 50 – to 60-day-old chickens presented pale mucosa, apathy, depression, ruffled feathers, and diarrhoea, accompanied by a 20% loss in fertile egg production, 20% culling of birds, and 5% mortality. The main findings at necropsy were marked intestinal dilatation with intestinal stasis, a narrow distal jejunum in the region of Meckel's diverticulum, and undigested food. Microscopic analysis revealed marked atrophic lymphoplasmacytic and heterophilic enteritis with hyperplastic crypts, ulceration, and heterophilic and lymphoplasmacytic perineuritis. The molecular assays consistently detected the presence of chicken parvovirus in the three segments of the intestine, pancreas, and proventriculus, as well as chicken megrivirus in the intestinal contents. Marked atrophic enteritis with perineuritis and intestinal stasis were associated with clinical manifestations of poor intestinal absorption and secondary bacterial infection. Our data provide useful information about IDS and highlight the importance of further studies to determine the specific role of each detected virus in this syndrome.
PB Taylor & Francis
SN 0307-9457
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/118003
UL https://hdl.handle.net/20.500.14352/118003
LA eng
NO Nuñez, L. F. N., Chacón, R. D., Charlys da Costa, A., Santander-Parra, S. H., da Costa Pereira Innocentini, R., Sánchez-Llatas, C. J., … Piantino Ferreira, A. J. (2024). Detection and molecular characterization of chicken parvovirus and chicken megrivirus in layer breeders affected by intestinal dilatation syndrome. Avian Pathology, 53(6), 520–532. https://doi.org/10.1080/03079457.2024.2372486
NO This work was supported by grants from CNPq (Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico) [grant number 453920/2014-4] and FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) [grant number FAPESP 2013/08560-5] and [grant number FAPESP 2015/09348-5]. A.J.P.F. was supported by CNPq [grant number 301084/2019-0].
NO Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico
NO Fundação de Amparo à Pesquisa do Estado de São Paulo
DS Docta Complutense
RD 7 abr 2025