RT Journal Article
T1 Differential colorectal carcinogenesis: Molecular basis and clinical relevance.
A1 Morán, Alberto
A1 Ortega Molina, Soledad Paloma
A1 Juan Chocano, María Del Carmen De
A1 Fernández Marcelo, Tamara
A1 Frías, Cristina
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Díaz-Rubio García, Eduardo
A1 Benito De Las Heras, Manuel R.
AB Colorectal cancer (CCR) is one of the most frequent cancers in developed countries. It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer. It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways. The traditional pathway, also called the suppressor or chromosomal instability pathway, follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes, such as K- ras, adenomatous polyposis coli, deleted in colorectal cancer, or p53. Alterations in the Wnt pathway are also very common in this type of tumour. The second main colorectal carcinogenesis pathway is the mutator pathway. This pathway is present in nearly 15% of all cases of sporadic colorectal cancer. It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes, mostly in hMLH1 or hMSH2. These two pathways have clear molecular differences, which will be reviewed in this article, but they also present distinct histopathological features. More strikingly, their clinical behaviours are completely different, having the "mutator" tumours a better outcome than the "suppressor" tumours. (C) 2010 Baishideng. All rights reserved.
PB BAISHIDENG PUBLISHING GROUP INC
SN 1948-5204
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/130320
UL https://hdl.handle.net/20.500.14352/130320
LA eng
NO Morán A, Ortega P, de Juan C, Fernández-Marcelo T, Frías C, Sánchez-Pernaute A, Torres AJ, Díaz-Rubio E, Iniesta P, Benito M. Differential colorectal carcinogenesis: Molecular basis and clinical relevance. World J Gastrointest Oncol. 2010 Mar 15;2(3):151-8. doi: 10.4251/wjgo.v2.i3.151. PMID: 21160823; PMCID: PMC2999176.
DS Docta Complutense
RD 26 feb 2026