RT Journal Article
T1 Short and long-term outcomes of COVID-19–associated venous thromboembolism: a propensity score–matched cohort study
A1 Alonso Beato, Rubén
A1 Demelo Rodríguez, Pablo
A1 Ordieres Ortega, Lucía
A1 López Rubio, Marina
A1 Lago Rodríguez, Marta Olimpia
A1 Oblitas, Crhistian Mario
A1 Álvarez-Sala Walther, Luis Antonio
A1 Galeano Valle, Francisco
AB Venous thromboembolism (VTE) is a recognized complication of SARS-CoV-2 infection, but its clinical features and both sort- and long-term outcomes remain incompletely characterized. We aimed to compare the clinical profile and outcomes of patients with VTE with and without recent COVID-19. We conducted a prospective cohort study including 2012 patients with objectively confirmed VTE. COVID-19–associated VTE was defined as VTE diagnosed within 30 days of a microbiologically confirmed SARS-CoV-2 infection. Clinical characteristics, treatment, and outcomes were compared between groups. Propensity score matching (1:1) and competing risk models were used to adjust for confounding. The primary outcomes-assessed at both 30 days and 365 days-included all-cause mortality, major bleeding, and VTE recurrence. A total of 272 patients (13.5%) had COVID-19–associated VTE. Compared with non-COVID cases, these patients more often had pulmonary embolism, higher D-dimer levels, and greater use of unfractionated heparin. At 30 days, COVID-19 was associated with increased mortality (HR 2.29; 95% CI 1.19–4.40) and major bleeding (HR 2.11; 95% CI 1.06–4.21). At one year, the bleeding risk remained higher (HR 1.54; 95% CI 1.02–2.33), while VTE recurrence was lower (HR 0.34; 95% CI 0.13–0.94). These results were consistent after propensity score matching. COVID-19-associated VTE is linked to worse short-term outcomes, including early mortality and bleeding, and to a persistently elevated bleeding risk at one year. Lower recurrence rates support the consideration of COVID-19 as a transient provoking factor.
PB Nature Springer Link
SN 1828-0447
SN 1970-9366
YR 2025
FD 2025-07-03
LK https://hdl.handle.net/20.500.14352/124538
UL https://hdl.handle.net/20.500.14352/124538
LA eng
NO Alonso-Beato, R., Demelo-Rodríguez, P., Ordieres-Ortega, L. et al. Short and long-term outcomes of COVID-19–associated venous thromboembolism: a propensity score–matched cohort study. Intern Emerg Med 20, 1835–1846 (2025). https://doi.org/10.1007/s11739-025-04042-x
NO 2025 Acuerdos transformativos CRUE
DS Docta Complutense
RD 19 mar 2026