RT Journal Article
T1 Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation
A1 Aparisi, Álvaro
A1 Ybarra Falcón, Cristina
A1 García Gómez, Mario
A1 Tobar, Javier
A1 Iglesias Echeverría, Carolina
A1 Jaurrieta Largo, Sofía
A1 Ladrón, Raquel
A1 Uribarri, Aitor
A1 Catalá, Pablo
A1 Hinojosa, Williams
A1 Marcos Mangas, Marta
A1 Fernández Prieto, Laura
A1 Sedano Gutiérrez, Rosa
A1 Cusacovich, Iván
A1 Andaluz Ojeda, David
A1 de Vega Sánchez, Blanca
A1 Recio Platero, Amada
A1 Sanz Patiño, Esther
A1 Calvo, Dolores
A1 Baladrón, Carlos
A1 Carrasco Moraleja, Manuel
A1 Disdier Vicente, Carlos
A1 Amat Santos, Ignacio J.
A1 San Román, J. Alberto
AB Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing with a cardiopulmonary exercise test (CPET), transthoracic echocardiogram, pulmonary lung test, six-minute walking test, serum biomarker analysis, and quality of life questionaries. Results: Patients with dyspnea (n = 41, 58.6%), compared with asymptomatic patients (n = 29, 41.4%), had a higher proportion of females (73.2 vs. 51.7%; p = 0.065) with comparable age and prevalence of cardiovascular risk factors. There were no significant differences in the transthoracic echocardiogram and pulmonary function test. Patients who complained of persistent dyspnea had a significant decline in predicted peak VO2 consumption (77.8 (64–92.5) vs. 99 (88–105); p < 0.00; p < 0.001), total distance in the six-minute walking test (535 (467–600) vs. 611 (550–650) meters; p = 0.001), and quality of life (KCCQ-23 60.1 ± 18.6 vs. 82.8 ± 11.3; p < 0.001). Additionally, abnormalities in CPET were suggestive of an impaired ventilatory efficiency (VE/VCO2 slope 32 (28.1–37.4) vs. 29.4 (26.9–31.4); p = 0.022) and high PETCO2 (34.5 (32–39) vs. 38 (36–40); p = 0.025). Interpretation: In this study, >50% of COVID-19 survivors present a symptomatic functional impairment irrespective of age or prior hospitalization. Our findings suggest a potential ventilation/perfusion mismatch or hyperventilation syndrome.
PB MDPI
SN 2077-0383
YR 2021
FD 2021-06-11
LK https://hdl.handle.net/20.500.14352/7409
UL https://hdl.handle.net/20.500.14352/7409
LA eng
NO The present study was partially granted by Gerencia Regional de Salud de Castilla y León under grant number GRS COVID 111/A/20 and a grant from the Spanish Society of Cardiology SEC/FEC-INVCLI 2.
NO Junta de Castilla y León. Gerencia Regional de Salud de Castilla y León
NO Sociedad Española de Cardiología
DS Docta Complutense
RD 7 abr 2025