RT Journal Article
T1 EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial
A1 Verdú Soriano, José
A1 De Cristino Espinar, Marisol
A1 Luna Morales, Silvia
A1 Dios Guerra, Caridad
A1 Casado Díaz, Antonio
A1 Quesada Gómez, José Manuel
A1 Dorado, Gabriel
A1 Berenguer Pérez, Miriam
A1 Vílchez, Susana
A1 Esquena, Jordi
A1 Rodríguez Mañas, Leocadio
A1 Lázaro Martínez, José Luis
AB Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we assessed the induction of acceleration of the early stages of wound healing as a secondary objective of a prospective, multicenter, randomized, observer-blinded, controlled trial. The patients were recruited if they had pressure, venous, or diabetic foot ulcers and were treated with EHO-85 (n = 103) or VariHesive® (SH) (n = 92), and their response was assessed by intention-to-treat as wound area reduction (WAR (%)) and healing rate (HR mm2/day) in the second and fourth weeks of treatment. Results: EHO-85 had the highest shear thinning and G′/G″ ratio, the lowest viscous modulus, G″, and relatively low cohesive energy; EHO-85 had a significantly superior effect over SH in WAR and HR, accelerating wound healing in the second and fourth weeks of application (p: 0.002). This superiority is likely based on its optimal moisturizing capacity and excellent pH-lowering and antioxidant properties. In addition, the distinct shear thinning of EHO-85 facilitates spreading by gentle hand pressure, making it easier to apply to wounds. These rheological properties contribute to its improved performance.
PB MDPI
SN 1999-4923
YR 2023
FD 2023-07-11
LK https://hdl.handle.net/20.500.14352/110665
UL https://hdl.handle.net/20.500.14352/110665
LA eng
NO Verdú-Soriano, J.; de Cristino-Espinar, M.; Luna-Morales, S.; Dios-Guerra, C.; Casado-Díaz, A.; Quesada-Gómez, J.M.; Dorado, G.; Berenguer-Pérez, M.; Vílchez, S.; Esquena, J.; et al. EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial. Pharmaceutics 2023, 15, 1925. https://doi.org/10.3390/pharmaceutics15071925
NO 2023 Descuento MDPI
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 11 abr 2025