RT Journal Article
T1 Targeting the cb2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis.
A1 de lago, 
A1 Rodríguez Cueto, Carmen Aurora
A1 García Toscano, Laura
A1 Santos García, Irene
A1 Gómez Almería, Marta
A1 Gonzalo Consuegra, Claudia
A1 Espejo Porras, Francisco
A1 Fernández Ruiz, José Javier
A1 Lago Femia, Eva De
AB Cannabinoids form a singular group of plant-derived compounds, endogenous lipids and synthetic derivatives with multiple therapeutic effects exerted by targeting different elements of the endocannabinoid system. One of their therapeutic applications is the preservation of neuronal integrity exerted by attenuating the multiple neurotoxic events that kill neurons in neurodegenerative disorders. In this review, we will address the potential of cannabinoids as neuroprotective agents in amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disorder characterized by muscle denervation, atrophy and paralysis, and progressive deterioration in upper and/or lower motor neurons. The emphasis will be paid on the cannabinoid type 2 (CB2 ) receptor, whose activation limits glial reactivity, but the potential of additional endocannabinoid-related targets will be also addressed. The evidence accumulated so far at the preclinical level supports the need to soon move towards the patients and initiate clinical trials to confirm the potential of cannabinoid-based medicines as disease modifiers in ALS.
PB Wiley
YR 2021
FD 2021-02-20
LK https://hdl.handle.net/20.500.14352/113427
UL https://hdl.handle.net/20.500.14352/113427
LA eng
NO Rodríguez-Cueto C, García-Toscano L, Santos-García I, Gómez-Almería M, Gonzalo-Consuegra C, Espejo-Porras F, Fernández-Ruiz J, de Lago E. Targeting the CB2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis. Br J Pharmacol. 2021 Mar;178(6):1373-1387. doi: 10.1111/bph.15386. Epub 2021 Feb 20. PMID: 33486755.
DS Docta Complutense
RD 4 abr 2025