RT Journal Article T1 Photoperiod-Dependent Effects on Blood Biochemical Markers of Phenolic-Enriched Fruit Extracts A1 Manocchio, Francesca A1 Morales, Diego A1 Navarro Masip, Elia A1 Aragonès, Gerard A1 Torres Fuentes, Cristina A1 Bravo, Francisca Isabel A1 Muguerza, Begoña AB Fruits are rich in bioactive compounds, such as (poly)phenols, and their intake is associated with health benefits, although recent animal studies have suggested that the photoperiod of consumption influences their properties. Fruit loss and waste are critical issues that can be reduced by obtaining functional fruit extracts. Therefore, the aim of this study was to obtain phenolic-enriched extracts from eight seasonal fruits that can modulate blood biochemical parameters and to investigate whether their effects depend on the photoperiod of consumption. Eight ethanol-based extracts were obtained and characterized, and their effects were studied in F344 rats exposed to short (6 h light, L6) and long (18 h light) photoperiods. Cherry and apricot extracts decreased blood triacylglyceride levels only when consumed under the L6 photoperiod. Pomegranate, grape, and orange extracts reduced cholesterol and fasting glucose levels during the L6 photoperiod; however, plum extract reduced fasting glucose levels only during the L18 photoperiod. The results showed the importance of photoperiod consumption in the effectiveness of phenolic-enriched fruit extracts and promising evidence regarding the use of some of the developed fruit extracts as potential functional ingredients for the management of several blood biomarkers. PB ACS SN 0021-8561 YR 2024 FD 2024 LK https://hdl.handle.net/20.500.14352/105433 UL https://hdl.handle.net/20.500.14352/105433 LA eng NO Francesca Manocchio, Diego Morales, Elia Navarro-Masip, Gerard Aragonès, Cristina Torres-Fuentes, Francisca Isabel Bravo, and Begoña Muguerza. Photoperiod-Dependent Effects on Blood Biochemical Markers of Phenolic-Enriched Fruit Extracts. Journal of Agricultural and Food Chemistry Article ASAP DOI: 10.1021/acs.jafc.4c01698 NO Ministerio de Ciencia e Innovación (España) DS Docta Complutense RD 10 abr 2025