RT Journal Article
T1 FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
A1 Agarwal, Devika
A1 Pineda Sanjuan, Silvia
A1 Michailidou, Kyriaki
A1 Herranz, J.
A1 Pita, Guillermo
A1 Moreno, T.
A1 Alonso, M. R.
A1 Dennis, Joe
A1 Wang, Qin
A1 Bolla, Manjeet
A1 Meyer, B.
A1 Menéndez Rodríguez, Primitiva
A1 Hardisson, David
A1 Mendiola, Marta
A1 González-Neira, Anna
A1 Lindblom, Annika
A1 Margolin, Sara
A1 Swerdlow, Anthony
A1 Ashworth, Alan
A1 Orr, Nick
A1 Jones, Michael
A1 Matsuo, Keitaro
A1 Ito, Hidemi
A1 Iwata, Hiroji
A1 Kondo, Naoto
A1 Hartman, Mikael
A1 Hui, Miao
A1 Lim, Wei Yee
A1 Iau, P. T. C.
A1 Sawyer, Elinor
A1 Tomlinson, Ian
A1 Kerin, Michael
A1 Miller, Nicola
A1 Kang, Daehee
A1 Choi, Ji Yeob
A1 Park, Sue
A1 Noh, Dong Young
A1 Hopper, John
A1 Schmidt, Daniel
A1 Makalic, Enes
A1 Southey, Melissa
A1 Teo, Soo
A1 Yip, Cheng Har
A1 Sivanandan, K.
A1 Tay, Tin
A1 Brauch, Hiltrud
A1 Brüning, Thomas
A1 Hamann, Ute
A1 Dunning, Alison
A1 Shah, Mitul
A1 Andrulis, Irene
A1 Knight, Julia
A1 Glendon, Gord
A1 Tchatchou, S.
A1 Schmidt, Marjanka
A1 Broeks, Annegien
A1 Rosenberg, E. H.
A1 van't Veer, L. J.
A1 Fasching, Peter
A1 Renner, S. P.
A1 Ekici, Arif
A1 Beckmann, Matthias
A1 Shen, Chen Yang
A1 Hsiung, Chia-Ni
A1 Yu, Jy-Cherng
A1 Blot, William
A1 Cai, Qiuyin
A1 Wu, Anna
A1 Tseng, Chiu-Chen
A1 Van Den Berg, David
A1 Stram, Daniel
A1 Cox, Angela
A1 Brock, Ian
A1 Reed, Malcom
A1 Muir, Kenneth
A1 Lophatananon, Artitaya
A1 Stewart-Brown, Sarah
A1 Siriwanarangsan, P.
A1 Zheng, Wei
A1 Deming Halverson, Sandra
A1 Shrubsole, Martha
A1 Long, Jirong
A1 Shu, Xiao-Ou
A1 Lu, W
A1 Gao, Yu-Tang
A1 Zhang, B.
A1 Radice, Paolo
A1 Peterlongo, Paolo
A1 Manoukian, Siranoush
A1 Mariette, F.
A1 Sangrajrang, Suleeporn
A1 McKay, James
A1 Couch, Fergus
A1 Toland, A. E.
A1 Yannoukakos, D.
A1 Fletcher, Olivia
A1 Johnson, Nicola
A1 dos Santos Silva, I.
A1 Peto, Julian
A1 Marme, F
A1 Burwinkel, Barbara
A1 Guénel, Pascal
A1 Truong, Thérèse
A1 Sánchez Beltrán, María Del Carmen
A1 Mulot, Claire
A1 Bojesen, Stig
A1 Nordestgaard, Borge
A1 Flyer, H.
A1 Brenner, Hermann
A1 Dieffenbach, A. K.
A1 Arndt, Volker
A1 Stegmaier, Christa
A1 Mannermaa, Arto
A1 Kataja, Vesa
A1 Kosma, Veli-Matti
A1 Hartikainen, Jaana
A1 Lambrechts, Diether
A1 Yesilyurt, B. T.
A1 Floris, G.
A1 Leunen, K.
A1 Chang-Claude, Jenny
A1 Rudolph, Anja
A1 Seibold, P.
A1 Flesch-Janys, Dieter
A1 Wang, X.
A1 Olson, Janet
A1 Vachon, Celine
A1 Purrington, K.
A1 Giles, Graham
A1 Severi, G.
A1 Baglietto, L.
A1 Haiman, Christopher
A1 Henderson, B. E.
A1 Schumacher, Fredrick
A1 Marchand, Loïc Le
A1 Simard, Jacques
A1 Dumont, Martine
A1 Goldberg, Mark
A1 Labréche, F.
A1 Winqvist, Robert
A1 Pylkäs, Katri
A1 Jukkola-Vuorinen, Arja
A1 Grip, Mervi
A1 Devilee, Peter
A1 Tollenaar, Rob
A1 Seynaeve, Caroline
A1 García-Closas, Montserrat
A1 Chanock, Stephen
A1 Lissowska, Jolanta
A1 Figueroa, Jonine
A1 Czene, Kamila
A1 Eriksson, Mikael
A1 Humphreys, Keith
A1 Darabi, H.
A1 Hooning, Maartje
A1 Kriege, Margriet
A1 Collée, Margriet
A1 Tilanus-Linthorst, M.
A1 Li, Jingmei
A1 Jakubowska, Anna
A1 Lubinski, Jan
A1 Jaworska-Bieniek, K.
A1 Durda, K
A1 Nevanlinna, Heli
A1 Muranen, T. A.
A1 Aittomäki, Kristiina
A1 Blomqvist, Carl
A1 Bogdanova, Natalia
A1 Dörk, Thilo
A1 Hall, Per
A1 Chenevix-Trench, Georgia
A1 Easton, Douglas
A1 Pharroah, Paul
A1 Arias-Perez, José Ignacio
A1 Zamora, P.
A1 Benítez, Javier
A1 Milne, Roger
A2 Evans, Jeff
AB Background: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods: Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression. Results: Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2. Conclusion: Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.
PB Springer Nature
SN 0007-0920
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/92074
UL https://hdl.handle.net/20.500.14352/92074
LA eng
NO Agarwal, D., Pineda Sanjuan, S., Michailidou, K. et al. «FGF Receptor Genes and Breast Cancer Susceptibility: Results from the Breast Cancer Association Consortium». British Journal of Cancer, vol. 110, n.o 4, febrero de 2014, pp. 1088-100. www.nature.com, https://doi.org/10.1038/bjc.2013.769.
DS Docta Complutense
RD 23 ene 2026