RT Journal Article
T1 Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy
A1 Delgado-Alonso, Cristina
A1 Delgado Álvarez, Alfonso
A1 Díez-Cirarda, María
A1 Oliver-Mas, Silvia
A1 Cuevas, Constanza
A1 Montero-Escribano, Paloma
A1 Ramos-Leví, Ana Maria
A1 Gil-Moreno, María José
A1 López-Carbonero, Juan Ignacio
A1 Hermann, Bruce P.
A1 Matías-Guiu Guía, Jorge
A1 Matias-Guiu, Jordi A.
AB Post-COVID condition (PCC) and multiple sclerosis (MS) share some clinical and demographic features, including cognitive symptoms and fatigue. Some pathophysiological mechanisms well-known in MS, such as autoimmunity, neuroinflammation and myelin damage, have also been implicated in PCC. In this study, we aimed to compare the cognitive phenotypes of two large cohorts of patients with PCC and MS, and to evaluate the relationship between fatigue and cognitive performance. Cross-sectional study including 218 patients with PCC and 218 with MS matched by age, sex, and years of education. Patients were evaluated with a comprehensive neuropsychological protocol and were categorized according to the International Classification of Cognitive Disorders system. Fatigue and depression were also assessed. Cognitive profiles of PCC and MS largely overlapped, with a greater impairment in episodic memory in MS, but with small effect sizes. The most salient deficits in both disorders were in attention and processing speed. The severity of fatigue was greater in patients with PCC. Still, the correlations between fatigue severity and neuropsychological tests were more prominent in the case of MS. There were no differences in the severity of depression among groups. Our study found similar cognitive profiles in PCC and MS. Fatigue was more severe in PCC, but was more associated with cognitive performance in MS. Further comparative studies addressing the mechanisms related to cognitive dysfunction and fatigue may be of interest to advance the knowledge of these disorders and develop new therapies.
PB Springer Nature
SN 2045-2322
YR 2024
FD 2024-04
LK https://hdl.handle.net/20.500.14352/103886
UL https://hdl.handle.net/20.500.14352/103886
LA eng
NO Delgado-Alonso, C., Delgado-Alvarez, A., Díez-Cirarda, M. et al. Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy. Sci Rep 14, 9806 (2024). https://doi.org/10.1038/s41598-024-60368-0
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
NO European Commission
DS Docta Complutense
RD 9 abr 2025