RT Journal Article
T1 Optimized Treatment of Nosocomial Peritonitis
A1 De Waele, Jan J.
A1 Coccolini, Federico
A1 Lagunes, Leonel
A1 Maseda, Emilio
A1 Rausei, Stefano
A1 Rubio Pérez, Inés
A1 Theodorakopoulou, Maria
A1 Arvaniti, Kostoula
AB This comprehensive review aims to provide a practical guide for intensivists, focusing on enhancing patient care associated with nosocomial peritonitis (NP). It explores the epidemiology, diagnosis, and management of NP, a significant contributor to the mortality of surgical patients worldwide. NP is, per definition, a hospital-acquired condition and a consequence of gastrointestinal surgery or a complication of other diseases. NP, one of the most prevalent causes of sepsis in surgical Intensive Care Units (ICUs), is often associated with multi-drug resistant (MDR) bacteria and high mortality rates. Early clinical suspicion and the utilization of various diagnostic tools like biomarkers and imaging are of great importance. Microbiology is often complex, with antimicrobial resistance escalating in many parts of the world. Fungal peritonitis and its risk factors, diagnostic hurdles, and effective management approaches are particularly relevant in patients with NP. Contemporary antimicrobial strategies for treating NP are discussed, including drug resistance challenges and empirical antibiotic regimens. The importance of source control in intra-abdominal infection management, including surgical and non-surgical interventions, is also emphasized. A deeper exploration into the role of open abdomen treatment as a potential option for selected patients is proposed, indicating an area for further investigation. This review underscores the need for more research to advance the best treatment strategies for NP.
PB MDPI
SN 2079-6382
YR 2023
FD 2023-12-11
LK https://hdl.handle.net/20.500.14352/110748
UL https://hdl.handle.net/20.500.14352/110748
LA eng
NO De Waele, J.J.; Coccolini, F.; Lagunes, L.; Maseda, E.; Rausei, S.; Rubio-Perez, I.; Theodorakopoulou, M.; Arvaniti, K. Optimized Treatment of Nosocomial Peritonitis. Antibiotics 2023, 12, 1711. https://doi.org/10.3390/antibiotics12121711
NO 2023 Descuento MDPI
DS Docta Complutense
RD 17 abr 2025