RT Journal Article
T1 Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality
A1 Parrón Ballesteros, Jorge
A1 García Gordo, Rubén
A1 López Rodríguez, Juan Carlos
A1 Olmo López, Nieves
A1 Villalba Díaz, María Teresa
A1 Batanero Cremades, Eva
A1 Turnay Abad, Francisco Javier
AB The “epithelial barrier hypothesis” states that a barrier dysfunction can result in allergy development due to tolerance breakdown. This barrier alteration may come from the direct contact of epithelial and immune cells with the allergens, and indirectly, through deleterious effects caused by environmental changes triggered by industrialization, pollution, and changes in the lifestyle. Apart from their protective role, epithelial cells can respond to external factors secreting IL-25 IL-33, and TSLP, provoking the activation of ILC2 cells and a Th2-biased response. Several environmental agents that influence epithelial barrier function, such as allergenic proteases, food additives or certain xenobiotics are reviewed in this paper. In addition, dietary factors that influence the allergenic response in a positive or negative way will be also described here. Finally, we discuss how the gut microbiota, its composition, and microbe-derived metabolites, such as short-chain fatty acids, alter not only the gut but also the integrity of distant epithelial barriers, focusing this review on the gut-lung axis.</jats:p>
PB Frontiers
SN 2673-6101
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/92363
UL https://hdl.handle.net/20.500.14352/92363
LA eng
NO Parrón-Ballesteros J, Gordo RG, López-Rodríguez JC, Olmo N, Villalba M, Batanero E, Turnay J. Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality.Front Allergy. 2023 Jan 30;4:1093800.
NO Ministerio de Ciencia y Educación (España)
DS Docta Complutense
RD 19 abr 2025