RT Journal Article
T1 Functional Connectivity Hypersynchronization in Relatives of Alzheimer’s Disease Patients: An Early E/I Balance Dysfunction?
A1 Ramírez Toraño, Federico
A1 Bruña Fernández, Ricardo
A1 De Frutos Lucas, Jaisalmer
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Marcos de Pedro, Silvia
A1 Delgado Losada, María Luisa
A1 Gómez-Ruiz, N.
A1 Barabash Bustelo, Ana
A1 Marcos Dolado, Alberto
A1 López Sánchez, Ramón
A1 Maestu Unturbe, Fernando
AB Alzheimer’s disease (AD) studies on animal models, and humans showed a tendency of the brain tissue to become hyperexcitable and hypersynchronized, causing neurodegeneration. However, we know little about either the onset of this phenomenon or its early effects on functional brain networks. We studied functional connectivity (FC) on 127 participants (92 middle-age relatives of AD patients and 35 age-matched nonrelatives) using magnetoencephalography. FC was estimated in the alpha band in areas known both for early amyloid accumulation and disrupted FC in MCI converters to AD. We found a frontoparietal network (anterior cingulate cortex, dorsal frontal, and precuneus) where relatives of AD patients showed hypersynchronization in high alpha (not modulated by APOE-ε4 genotype) in comparison to age-matched nonrelatives. These results represent the first evidence of neurophysiological events causing early network disruption in humans, opening a new perspective for intervention on the excitation/inhibition unbalance.
PB Oxford academic
SN 1047-3211
SN 1460-2199
YR 2020
FD 2020-10-27
LK https://hdl.handle.net/20.500.14352/102344
UL https://hdl.handle.net/20.500.14352/102344
LA eng
NO Ramírez-Toraño, F., Bruña, R., de Frutos-Lucas, J., Rodríguez-Rojo, I. C., Marcos de Pedro, S., Delgado-Losada, M. L., Gómez-Ruiz, N., Barabash, A., Marcos, A., López-Higes, R., & Maestú, F. (2021). Functional connectivity hypersynchronization in relatives of Alzheimer’s disease patients: an early E/I balance dysfunction?. Cerebral Cortex, 31(2), 1201-1210.
NO Ministerio de Economía y Competitividad
NO Comunidad de Madrid
NO Fundación La Caixa
DS Docta Complutense
RD 6 abr 2025