RT Journal Article
T1 Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake
A1 Liñares-Pose, Laura
A1 Rial-Pensado, Eva
A1 Estévez-Salguero, Ánxela
A1 Milbank, Edward
A1 González-García, Ismael
A1 Rodríguez Prados, Claudia
A1 Seoane-Collazo, Patricia
A1 Martinez-Sánchez, Noelia
A1 Nogueiras, Rubén
A1 Prieto Ocejo, Dolores
A1 Diéguez, Carlos
A1 Contreras Jiménez, Cristina
A1 López, Miguel
AB Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein kinase (AMPK). Herein, we aimed to investigate whether genetic over-expression of GRP78 in the ventromedial nucleus of the hypothalamus (VMH: a key site regulating thermogenesis) could ameliorate very high fat diet (vHFD)-induced obesity. Our data showed that stereotaxic treatment with adenoviruses harboring GRP78 in the VMH reduced hypothalamic endoplasmic reticulum ER stress and reversed vHFD-induced obesity. Herein, we also demonstrated that this body weight decrease was more likely associated with an increased BAT thermogenesis and browning of white adipose tissue (WAT) than to anorexia. Overall, these results indicate that the modulation of GRP78 in the VMH may be a target against obesity.
PB MDPI
SN 2073-4425
YR 2018
FD 2018-07-17
LK https://hdl.handle.net/20.500.14352/12665
UL https://hdl.handle.net/20.500.14352/12665
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO Ministerio de Economía y Competitividad (MINECO)
NO Xunta de Galicia
DS Docta Complutense
RD 7 abr 2025