RT Journal Article
T1 Increase in Incidence Rates and Risk Factors for Multidrug Resistant Bacteria in Septic Children: A Nationwide Spanish Cohort Study (2013–2019)
A1 Slocker Barrio, María
A1 López-Herce Cid, Jesús
A1 Bustinza Arriortúa, Amaya
A1 Fresán Ruiz, Elena
A1 Jordán García, Iolanda
A1 De Carlos Vicente, Juan Carlos
A1 Morteruel Arizcuren, Elvira
A1 García Soler, Patricia
A1 Nieto Moro, Montserrat
A1 Schüffelmann, Cristina
A1 Belda Hofheinz, Sylvia
A1 Herrera Castillo, Laura Ximena
A1 Uriona Tuma, Sonia María
A1 Pinós Tella, Laia
A1 Peña López, Yolanda
AB The emergence of multidrug-resistant (MDR) bacteria in children is a growing concern, particularly among septic patients, given the need for first-right dosing. Our aim was to determine the incidence rates and factors associated with MDR-sepsis in the pediatric intensive care unit (PICU), using data from the Spanish ENVIN-HELICS PICU registry between 2013 and 2019. The rate of MDR bacteria among septic children ranged between 5.8 and 16.2% throughout this study period, with a significant increase since 2015 (p = 0.013). MDR-gram-negative bacteria (92%), particularly EBL-Enterobacterales (63.7%), were the most frequent causative microorganisms of MDR-sepsis. During this study period, sixteen MDR-sepsis (32.6%) corresponded to intrahospital infections, and 33 (67.4%) had community-onset sepsis, accounting for 10.5% of the overall community-onset sepsis. Independent risk factors associated with MDR-sepsis were antibiotics 48 h prior to PICU admission (OR 2.38) and PICU onset of sepsis (OR 2.58) in >1 year-old children, and previous malnourishment (OR 4.99) in <1 year-old children. Conclusions: There was an alarming increase in MDR among septic children in Spain, mainly by gram-negative (ESBL-Enterobacterales), mostly coming from the community setting. Malnourished infants and children on antibiotics 48 h prior to PICU are at increased risk and therefore require closer surveillance.
PB MDPI
SN 2079-6382
YR 2023
FD 2023-11-14
LK https://hdl.handle.net/20.500.14352/110759
UL https://hdl.handle.net/20.500.14352/110759
LA eng
NO Slocker-Barrio, M.; López-Herce-Cid, J.; Bustinza-Arriortúa, A.; Fresán-Ruiz, E.; Jordán-García, I.; de Carlos-Vicente, J.C.; Morteruel-Arizcuren, E.; García-Soler, P.; Nieto-Moro, M.; Schüffelmann, C.; et al. Increase in Incidence Rates and Risk Factors for Multidrug Resistant Bacteria in Septic Children: A Nationwide Spanish Cohort Study (2013–2019). Antibiotics 2023, 12, 1626. https://doi.org/10.3390/antibiotics12111626
NO 2023 Descuento MDPI
DS Docta Complutense
RD 9 abr 2025