%0 Journal Article
%A Cicuéndez Maroto, Mónica
%A Portolés Pérez, María Teresa
%A Izquierdo Barba, Isabel
%A Vallet Regí, María Dulce Nombre
%T New nanocomposite system with nanocrystalline apatite embedded into mesoporous bioactive glass
%D 2012
%@ 0897-4756
%U https://hdl.handle.net/20.500.14352/96645
%X Crystalline nanoparticles are very attractive building blocks for the preparation of nanostructured materials. These particles can be dispersed in different noncrystalline mesostructured matrixes in order to obtain nano-composite systems which combine the properties of both components broadening their functionality. In the present study, a novel nanocomposite bioceramic formed by nanocrystalline apatite particles uniformly embedded into a mesostructured SiO2−CaO−P2O5 glass wall has been synthesized through the evaporation-induced self-assembly (EISA) method, commonly used for mesoporous bioactive glass synthesis, but accelerating the sol−gel apatite crystallization rate by strong acidification. Moreover, the use of F127 surfactant as a structure directing agent in this synthesis has allowed the homogeneous nanocrystalline apatite particles incorporation inside of the amorphous mesoporous glass. In vitro bioactive assays have shown a fast apatite-like phase formation similar to that exhibited by mesoporous bioactive glasses. Furthermore, the response of L929 fibroblasts and Saos-2 osteoblasts to this new nanocomposite has indicated a significant improvement in its biocompatibility compared with conventional mesoporous bioactive glasses.
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