%0 Journal Article
%A Manzano, Mónica
%A Talavera Rodríguez, Alba
%A Moreno, Elena
%A Madrid, Nadia
%A Gosalbes, María José
%A Ron, Raquel
%A Dronda, Fernando
%A Pérez Molina, José A.
%A Lanza, Val F.
%A Díaz, Jorge
%A Moreno, Santiago
%A Navia, Beatriz
%A Serrano Villar, Sergio
%T Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
%D 2022
%@ 2072-6643
%U https://hdl.handle.net/20.500.14352/72524
%X While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.
%~