RT Journal Article
T1 Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
A1 Manzano, Mónica
A1 Talavera Rodríguez, Alba
A1 Moreno, Elena
A1 Madrid, Nadia
A1 Gosalbes, María José
A1 Ron, Raquel
A1 Dronda, Fernando
A1 Pérez Molina, José A.
A1 Lanza, Val F.
A1 Díaz, Jorge
A1 Moreno, Santiago
A1 Navia, Beatriz
A1 Serrano Villar, Sergio
AB While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.
PB MPDI
SN 2072-6643
YR 2022
FD 2022-03-14
LK https://hdl.handle.net/20.500.14352/72524
UL https://hdl.handle.net/20.500.14352/72524
LA eng
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
DS Docta Complutense
RD 18 abr 2025