RT Journal Article
T1 Intracellular pH-Induced Tip-to-Tip Assembly of Gold Nanorods for Enhanced Plasmonic Photothermal Therapy
A1 Ahijado Guzmán, Rubén
A1 González Rubio, Guillermo
A1 Izquierdo, Jesús G.
A1 Bañares Morcillo, Luis
A1 López-Montero, Iván
A1 Calzado Martín, Alicia
A1 Calleja, Montserrat
A1 Tardajos Rodríguez, Gloria
A1 Guerrero Martínez, Andrés
AB The search for efficient plasmonic photothermal therapies using nonharmful pulse laser irradiation at the near-infrared (NIR) is fundamental for biomedical cancer research. Therefore, the development of novel assembled plasmonic gold nanostructures with the aim of reducing the applied laser power density to a minimum through hot-spot-mediated cell photothermolysis is an ongoing challenge. We demonstrate that gold nanorods (Au NRs) functionalized at their tips with a pH-sensitive ligand assemble into oligomers within cell lysosomes through hydrogen-bonding attractive interactions. The unique intracellular features of the plasmonic oligomers allow us to significantly reduce the femtosecond laser power density and Au NR dose while still achieving excellent cell killing rates. The formation of gold tip-to-tip oligomers with longitudinal localized surface plasmon resonance bands at the NIR, obtained from low-aspect-ratio Au NRs close in resonance with 800 nm Ti:sapphire 90 fs laser pulses, was found to be the key parameter for realizing the enhanced plasmonic photothermal therapy.
PB American Chemical Society
SN 2470-1343
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/23742
UL https://hdl.handle.net/20.500.14352/23742
LA eng
NO The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n° 338133)
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 6 may 2024