RT Journal Article T1 Medication related to pigmentation of oral mucosa A1 Mallagray-Montero, M-C A1 Moreno López, Luis Alberto A1 Cerero Lapiedra, Rocío A1 Castro-Janeiro, M A1 Madrigal Martínez-Pereda, Cristina María AB Background: The diagnosis of oral melanotic lesions is, more often than not, challenging in the clinical practice due to the fact that there are several reasons which may cause an increase in pigmentation on localized or generalized areas. Among these, medication stands out.Material and methods: In this work, we have carried out a review in the reference pharma database: Micromedex® followed by a review of the scientific published literature to analyse coincidences and possible discrepancies.Results: Our findings show that there are several prescription drugs that can cause pigmented lesions in the oral mucosa. This must be known by clinicians in order to properly diagnose pigmented lesions. We have identified a set of 21 medicaments which cause these lesions, some of which are used frequently in the clinic, such as Metronidazole, Amitriptyline, conjugated oestrogens and Chlorhexidine gluconate. We also found discrepancies with the data published in specialized literature, some of which wasn't reflected in the Summary of Product Characteristics.Conclusions: Our work highlights the importance of the proper communication of adverse drug reactions (ADR) by health professionals in order to provide thorough and accurate information and diagnosis. PB Medicina Oral SN 1698-4447 YR 2022 FD 2022-05 LK https://hdl.handle.net/20.500.14352/115308 UL https://hdl.handle.net/20.500.14352/115308 LA eng NO Mallagray-Montero MC, Moreno-López LA, Cerero-Lapiedra R, Castro-Janeiro M, Madrigal-Martínez-Pereda C. Medication related to pigmentation of oral mucosa. Med Oral Patol Oral Cir Bucal. 2022 May 1;27(3):e230-e237. DS Docta Complutense RD 5 abr 2025