RT Journal Article
T1 Infectious Complications Following Pancreatic Transplantation: Incidence, Microbiological and Clinical Characteristics, and Outcome
A1 Lumbreras Bermejo, Carlos Juan
A1 Fernández Fernández, María Inmaculada
A1 Velosa, J.
A1 Munn, S.
A1 Sterioff, S.
A1 Paya, C.V.
AB The infectious complications following pancreatic transplantation in 34 consecutive recipients were analyzed during a mean follow-up of 39 months. Twenty-seven recipients (79%) developed a mean of 2.1 serious infectious complications. Three of the six deaths (overall mortality, 18%) were infection related. Thirty-three percent of severe infectious episodes were caused by bacteria (72% by gram-positive cocci) and 26% by fungi (87% by Candida species); severe cytomegalovirus (CMV) infection accounted for 33% of infectious complications. CMV disease and organ involvement occurred most frequently in the donor-seropositive/recipient-seronegative group (36%), followed by the donor-seronegative/recipient-seropositive group (25%). In four patients (12%) Epstein-Barr virus (EBV)-related posttransplantation lymphoproliferative disease (PTLD) developed, directly resulting in two deaths. PTLD developed in two of the three EBV-seronegative and two of the 31 EBV-seropositive recipients. Infections due to herpes simplex and zoster viruses and Pneumocystis carinii (2, 3, and 1, respectively) developed in 6 patients. The use of OKT3 for rejection therapy was associated with symptomatic CMV disease and EBV-related PTLD. In summary, severe infectious complications are the main cause of morbidity and death among patients who undergo pancreas transplantation. Aggressive antimicrobial prophylactic regimens are required to decrease the effects of such complications.
PB Oxford University Press
SN 1058-4838
SN 1537-6591
YR 1995
FD 1995-03-01
LK https://hdl.handle.net/20.500.14352/113712
UL https://hdl.handle.net/20.500.14352/113712
LA eng
NO C. Lumbreras, I. Fernandez, J. Velosa, S. Munn, S. Sterioff, C. V. Paya, Infectious Complications Following Pancreatic Transplantation: Incidence, Microbiological and Clinical Characteristics, and Outcome, Clinical Infectious Diseases, Volume 20, Issue 3, March 1995, Pages 514–520, https://doi.org/10.1093/clinids/20.3.514
DS Docta Complutense
RD 7 abr 2025