RT Journal Article
T1 Tailoring the biological response of mesoporous bioactive materials
A1 Gómez Cerezo, María Natividad
A1 Izquierdo Barba, Isabel
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
AB Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and ε-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic (levofloxacin) and an antitumoral drug (doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.
PB Elsevier
SN 2050-750X
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/95544
UL https://hdl.handle.net/20.500.14352/95544
LA eng
NO Gómez-Cerezo N, Izquierdo-Barba I, Arcos D, Vallet-Regí M. Tailoring the biological response of mesoporous bioactive materials. J Mater Chem B 2015;3:3810–9. https://doi.org/10.1039/C5TB00268K.
NO Ministerio de Ciencia e Innovacion (España)
NO Ministerio de Economía y Competitividad (España)
NO Agening Network of Excellence
DS Docta Complutense
RD 20 ene 2026