RT Journal Article
T1 Development and growth of median structures in the human tongue: A histological study using human fetuses and adult cadavers
A1 Yamamoto, Masahito
A1 Hirota, Yoshinosuke
A1 Watanabe, Genji
A1 Taniguchi, Shuichiro
A1 Murakami, Gen
A1 Rodríguez Vázquez, José Francisco
A1 Abe, Shinichi
AB Glossectomy is a surgical procedure performed to remove all or part of the tongue in patients with cancer. The removal of a significant part of the tongue has a marked effect on speech and swallowing function, as patients may lose not only the tongue muscles but also the median lingual septum (MLS). Therefore, to achieve successful tongue regeneration, it is necessary to investigate the developmental processes of not only the tongue muscles but also the MLS. This study was conducted to clarify the mutual development of the tongue muscles and the MLS in human fetuses. Serial or semi-serial histological sections from 37 embryos and fetuses (aged 5-39 weeks) as well as nine adults were analyzed. The MLS appeared at Carnegie stage 15 (CS15), and until 12 weeks of gestation, abundant fibers of the intrinsic transverse muscle crossed the septum in the entire tongue. However, in near-term fetuses and adults, the contralaterally extending muscles were restricted to the deepest layer just above the genioglossus muscle. This finding indicates that the crossing transverse muscle showed the highest density at mid-term. A thorough understanding of both the MLS and the tongue muscles is necessary for successful tongue regeneration.
PB Wiley
SN 1932-8486
YR 2023
FD 2023-03-20
LK https://hdl.handle.net/20.500.14352/108972
UL https://hdl.handle.net/20.500.14352/108972
LA eng
NO Yamamoto, M., Hirota, Y., Watanabe, G., Taniguchi, S., Murakami, G., Rodríguez-Vázquez, J. F., & Abe, S. I. (2024). Development and growth of median structures in the human tongue: A histological study using human fetuses and adult cadavers. Anatomical record (Hoboken, N.J. : 2007), 307(2), 426–441. https://doi.org/10.1002/ar.25198
DS Docta Complutense
RD 15 dic 2025