RT Journal Article T1 Physiological response during activity programs using Wii-based video games in patients with cystic fibrosis (CF) A1 Del Corral Núñez-Flores, Tamara A1 Percegona, Janaína A1 Seborga, Melisa A1 Rabinovich, Roberto A A1 Vilaró, Jordi AB Patients with cystic fibrosis (CF) are characterized by an abnormal ventilation response that limits the exercise capacity. Exercise trainingincreases exercise capacity, decreases dyspnea and improves health-related quality of life in CF. Adherence to pulmonary rehabilitation programsis a key factor to guarantee optimal benefits and a difficult goal in this population.The aim of this study was to determine the physiological response during three Nintendo Wii™ video game activities (VGA) candidates to beused as training modalities in patients with CF.Method: 24 CF patients (age 12.6 ± 3.7 years; BMI 18.8 ± 2.9 kg m−2; FEV1 93.8 ± 18.8 %pred) were included.All participants performed, on two separate days, 3 different VGA: 1) Wii Fit Plus (Wii-Fit); 2) Wii Active (Wii-Acti), and 3) Wii Family Trainer(Wii-Train), in random order during 5 min. The obtained results were compared with the 6-min walk test (6MWT). The physiological variables [oxygenuptake (VO2), minute ventilation (VE), and heart rate (HR)] were recorded using a portable metabolic analyzer.Results: During all VGA and 6MWT, VO2 reached a plateau from the 3rd min. Compared with the 6MWT (1024.2 ± 282.2 mL m−1), Wii-Acti(1232.2 ± 427.2 mL m−1) and Wii-Train (1252.6 ± 360.2 mL m−1) reached higher VO2 levels during the last 3 min (p b 0.0001 in both cases), whileWii-Fit (553.8 ± 113.2 mL m−1) reached significantly lower levels of VO2 (p b 0.001). Similar effects were seen for the ventilatory volume (VE). Nodifferences in dyspnea and oxygen saturation were seen between the different modalities. All patients were compliant with all three Wii™ modalities.Conclusion: Active video game are well tolerated by patients with CF. All the modalities evaluated imposed a constant load but were associated withdifferent physiological responses reflecting the different intensities imposed. Wii-Acti and Wii-Train impose a significantly high metabolic demandcomparable to the 6MWT. Further research is needed to evaluate the effects of VGA as a training program to increase exercise capacity for CF patients. PB Elsevier B.V. SN 1569-1993 YR 2014 FD 2014-06-13 LK https://hdl.handle.net/20.500.14352/94297 UL https://hdl.handle.net/20.500.14352/94297 LA eng NO del Corral T, Percegona J, Seborga M, Rabinovich RA, Vilaró J. Physiological response during activity programs using Wii-based video games in patients with cystic fibrosis (CF). J Cyst Fibros. 2014 Dec;13(6):706-11. doi: 10.1016/j.jcf.2014.05.004. Epub 2014 Jun 13. PMID: 24935613. DS Docta Complutense RD 7 abr 2025