RT Journal Article T1 Cell adhesion molecules E-cadherin and CADM1 are differently expressed in canine inflammatory mammary cancer A1 Alonso Díez, Ángela A1 Affolter, V.K. A1 Sevane Fernández, Natalia A1 Dunner Boxberger, Helene Susana A1 Valdivia Lara, Edgar Guillermo A1 Clemente, Mónica A1 Andrés Gamazo, Paloma Jimena de A1 Illera Del Portal, Juan Carlos A1 Pérez Alenza, María De Los Dolores A1 Fernández Peña, Laura AB Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most aggressive and lethal types of mammary tumors with specific characteristics such as exacerbated angiogenesis, lymphangiogenesis and lymphangiotropism. E-cadherin expression is another specific feature of IBC not previ ously studied in canine IMC. In this study, the expression of E-cadherin and CADM1 (Cell Adhesion molecule 1) and their possible role as key molecules involved in the pathogenesis of IMC were immunohistochemically analyzed in 19 canine IMC and 15 grade III non-IMC cases. E-cadherin and CADM1 expression was higher in IMC cases (p = 0.002, p = 0.008, respectively). In the IMC group, E-cadherin cytoplasmic immunolabeling was more frequent (p = 0.035) and it was associated to the expression of the angiogenic and lymphangiogenic factors COX2 (p = 0.009), VEGF-A (p = 0.031) and VEGF-D (p = 0.008). The differential mRNA expression between IMC and non-IMC was studied by microarray analysis in 6 cases. E-cadherin gene (CDH1) was not up-regulated in IMC cases at a transcriptional level; interestingly CADM1 was 7-fold upregulated. The differential expression of Ecadherin protein in IMC suggests a possible role of E-cadherin in the characteristic exacerbated angiogenesis and lymphangiogenesis and further support IMC as a natural model for the study of human IBC. Future studies in IBC and IMC including a broad panel of adhesion molecules are necessary to elucidate their role in the metastatic process and angiogenesis. PB Elsevier SN 0034-5288 YR 2022 FD 2022 LK https://hdl.handle.net/20.500.14352/117977 UL https://hdl.handle.net/20.500.14352/117977 LA eng NO Alonso-Diez, Affolter, Sevane, Dunner, Valdivia, Clemente, De Andrés, Illera, Pérez-Alenza, & Peña. (2022). Cell adhesion molecules E-cadherin and CADM1 are differently expressed in canine inflammatory mammary cancer. Research in Veterinary Science, 152, 307-313. https://doi.org/10.1016/J.RVSC.2022.08.027 NO Ministerio de Ciencia, Innovación y Tecnología (España) NO Universidad Complutense Madrid DS Docta Complutense RD 11 abr 2025