RT Journal Article
T1 Synchrony relationships between the left ventricle and a left ventricular assist device: an experimental study in pigs
A1 Heredero, Ángeles
A1 PérezCaballero, Ramón
A1 Otero, Javier
A1 Rodríguez Martínez, Daniel
A1 Quintana Villamandos, María Begoña
A1 Rodríguez Bernal, Guillermo Juan
A1 González Pinto, Ángel Tomás
A1 Ruiz Fernández, Manuel
A1 Cañizo López, Juan Francisco Del
AB Background: Synchronization between the left ventricle and a left ventricular assist device (LVAD) may be important for ventricular unloading and coronary perfusion. We assessed the synchrony between cardiac and LVAD cycles by increasing delays in steps of 100 msec throughout the cycle, under conditions of total and partial left ventricular support.Methods: We studied 7 healthy minipigs weighing 30-40 kg. A 60-cc Berlin Heart Excor LVAD was implanted and connected to a BCM 1200 console, making it possible to synchronize the LVAD systole and the EKG signal with a prefixed delay. We recorded hemodynamic parameters (including aortic, pulmonary, and left ventricular pressure) and LVAD flow for each delay.Results: Intraventricular pressure during LVAD systole was minimized with delays of around 40-80% of one cycle. In addition, total flow was higher under these conditions.Conclusions: This study shows that the synchronous mode of LVAD operation is feasible. Moreover, a delay in device contraction until the second half of the cardiac cycle optimizes ventricular unloading and may eventually improve myocardial recovery
PB SAGE Publications
SN 0391-3988
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/98043
UL https://hdl.handle.net/20.500.14352/98043
LA eng
NO Heredero A, Perez-Caballero R, Otero J, Rodríguez-Martínez D, Quintana-Villamandos B, Rodríguez-Bernal G, González-Pinto Á, Ruiz-Fernandez M, Del Cañizo JF. Synchrony relationships between the left ventricle and a left ventricular assist device: an experimental study in pigs. Int J Artif Organs. 2012 Apr 30;35(4):272-8. doi: 10.5301/ijao.5000086
DS Docta Complutense
RD 17 jun 2025