RT Journal Article
T1 Targeting cow's milk allergy using hypoallergenic protein-polyphenol formulas: A proof of concept
A1 Victoria Gil, M.
A1 Gutiérrez Díaz, Gloria
A1 Higuero, Nieves
A1 Palma, Esther
A1 Fernández Rivera, Nuria
A1 Parrón Ballesteros, Jorge
A1 Betancor, Diana
A1 Pastor Vargas, Carlos
A1 Cintas, Pedro
A1 Delgado Adamez, Jonathan
AB Cow's milk allergy caused by a hypersensitivity to milk proteins has increased over the last years. Hypoallergenic responses can be induced by altering the structure of such proteins with chemical modifiers; this paper is about the creation of edible matrices based on polyphenols from orange peel. Some compounds were able to significantly lower the IgE binding from β-lactoglobulin allergic serum in sensitized patients. Such effects could also be observed for casein allergic serum in patients sensitized to both proteins. A certain inter-individual variability is observed, although polyphenols do actually induce salient structural changes. This indicates that molecular modifications aimed at oral treatments against food allergy may or may not correlate with reduced allergenicity, and hence the necessity for serum monitoring through immunological assays. Overall, the results are promising enough to validate the polyphenol-fortified approach. In addition, this study highlights the upgrading of vegetable waste, consistent with a circular economy in food chemistry.
PB Elsevier
SN 0308-8146
YR 2025
FD 2025-01-15
LK https://hdl.handle.net/20.500.14352/118292
UL https://hdl.handle.net/20.500.14352/118292
LA eng
NO Gil, M. Victoria, et al. «Targeting Cow’s Milk Allergy Using Hypoallergenic Protein-Polyphenol Formulas: A Proof of Concept». Food Chemistry, vol. 463, enero de 2025, p. 141285. DOI.org (Crossref), https://doi.org/10.1016/j.foodchem.2024.141285.
NO Supplementary Material: Regression plots, chromatograms (HPLC analyses) showing the composition and concentration of polyphenols present in orange peels extracts and polyphenol-protein matrices in the supernatants, as well as additional FT-IR spectra of native proteins and their modified secondary structure by non-covalent interactions with phenolics.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Junta de Extremadura (España)
NO European Regional Development Fund
NO Ministerio de Ciencia y Educación (España)
DS Docta Complutense
RD 8 jun 2025