RT Journal Article
T1 Development of hybrid nanomaterials based on MXene/Fe3O4 magnetic nanoparticles for photo-magnetic hyperthermia applications
A1 Zhu, Peng Shen
A1 Cabanelas, Juan Carlos
A1 Gallo-Córdova, Álvaro
A1 Gutiérrez, Lucía
A1 Fernández-Afonso, Yílian
A1 Miguela, Verónica S
A1 Cuenca, Julio Marco
A1 Maroto Valiente, Ángel
A1 Gavilán Rubio, Helena
A1 Serrano, María B
AB MXenes are two-dimensional transition metal carbides that have emerged as versatile nanomaterials. Their distinctive physicochemical properties and surface characteristics2 make them ideal platforms for engineering hybrid nanomaterials. The combination of MXenes and magnetic nanoparticles (MNPs) into a single nano-object leads to materials with interesting properties (ferrimagnetism, mechanical strength, and conductivity, etc.) for a broad range of applications. MXenes exhibit good compatibility and excellent photothermal (PTT) properties; while MNPs, particularly iron oxide nanoparticles (IONPs), are exploited for biomedical applications through magnetic hyperthermia (MHT). This work focuses on the development of hybrid nanomaterials combining MXenes and IONPs, prepared through a simple, holistic, and reproducible method. The surface of delaminated MXenes (dMXenes) sheets was covered with well-defined shape IONPs of 14 nm. We have used faceted nanoparticles, to achieve point-of-reference magnetic hyperthermia performance. The surface loading of IONPs on the MXenes was controlled by varying the MXene-to-MNPs mass ratio from 10:90 to 90:10. The potential of the hybrids for photo-magnetic hyperthermia was evaluated using near-infrared (NIR) light (1064 nm, 1 W) and alternating magnetic fields (AMFs) of 9.5–17.0 kA/m and 282 kHz, determining their specific absorption rates (SAR) values. While for MHT, SAR values are up to 150 W/g (Fe3O4) for 50:50 hybrid, the characterization of this new nanomaterial revealed a synergistic behavior in PTT, achieving SAR values up to 577 and 1106 W/g (hybrid), for 50:50 and 70:30 mass ratio hybrids, respectively. This work demonstrates the heat dissipation capability of MXene/IONPs hybrids under AMFs and via laser excitation.
PB Elsevier
YR 2025
FD 2025-10-28
LK https://hdl.handle.net/20.500.14352/130433
UL https://hdl.handle.net/20.500.14352/130433
LA eng
NO Zhu Peng Shen, Juan Carlos Cabanelas, Álvaro Gallo-Cordova, Lucía Gutiérrez, Yílian Fernández-Afonso, Verónica S Miguela, Julio Marco Cuenca, Ángel MarotoValiente, Helena Gavilán, María B Serrano (2025). Development of hybrid nanomaterials based mxene/magnetic nanoparticles for photo-magnetic hyperthermia applications. 10.2139/ssrn.5118355
NO PID2021-125302NB-I00
NO MCIN/AEI/ 10.13039/501100011033
NO ERDF A way of making Europe
NO RYC2021‐032448‐I
NO TED2021-130191B-C43
NO COST Action CA23132 (NexMPI)
NO COST (European Cooperation in Science and Technology)
NO Universidad Carlos III de Madrid
DS Docta Complutense
RD 26 feb 2026