RT Journal Article
T1 Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites
A1 Silva, Mariana
A1 Cueva, Carolina
A1 Alba Rubio, Claudio
A1 Rodríguez Gómez, Juan Miguel
A1 Pascual-Teresa, Sonia de
A1 Jones, Jonathan
A1 Caturla, Nuria
A1 Moreno-Arribas, M. Victoria
A1 Bartolomé, Begoña
AB This paper investigates the impact of a polyphenol-enriched supplement comprised of hibiscus (Hibiscus sabdariffa) and lemon verbena (Lippia Citriodora) (brand name Metabolaid®) on gut microbiota composition and functionality, by performing fermentations with human faecal microbiota under gut-simulated conditions. Results indicated that Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome to higher relative abundances of some major genera (>3% of relative abundance) such as Bifidobacterium, Blautia and Faecalibacterium and of other minor genera such as Prevotella and Akkermansia. Metabolaid® also promoted increases in short-chain fatty acids (SCFAs) production, particularly butyric acid. On the other hand, it was confirmed that the compounds present in the Metabolaid® supplement (anthocyanins, verbascoside and hibiscus acid) were rapidly metabolized by the gut microbiota. Overall, these results reveal a certain level of gut microbiota-modulating properties of Metabolaid® that could be implicated, at least partially, in the mechanisms behind the potential beneficial effects of this supplement in obesity.
PB Elsevier
SN 1756-4646
YR 2022
FD 2022-04
LK https://hdl.handle.net/20.500.14352/101061
UL https://hdl.handle.net/20.500.14352/101061
LA eng
NO Ministerio de Ciencia e Innovación (PID2019-108851RB-C21)
NO Comunidad de Madrid (ALIBIRD-CM 2020 P2018/BAA-4343)
DS Docta Complutense
RD 20 ene 2026