RT Journal Article
T1 Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
A1 Aracil Moreno, Irene
A1 Rodríguez Benitez, Patrocinio
A1 Ruiz Minaya, Maria
A1 Bernal Claverol, Mireia
A1 Ortega Abad, Virginia
A1 Hernández Martin, Concepción
A1 Pintado Recarte, Pilar
A1 Yllana, Fátima
A1 Oliver Barrecheguren, Cristina
A1 Álvarez Mon, Melchor
A1 Ortega, Miguel A.
A1 De León Luis, Juan Antonio
AB Preeclampsia is one of the most worrisome complications during pregnancy, affecting approximately 1 out of 20 women worldwide. Preeclampsia is mainly characterized by a sustained hypertension, proteinuria, also involving a significant organ dysfunction. Moreover, 25% of the cases could be classified as severe preeclampsia (SP), a serious condition that could be life-threatening for both the mother and fetus. Although there are many studies focusing on preeclampsia, less efforts have been made in SP, frequently limited to some specific situations. Thus, the present study aims to conduct a comparative analysis of risk factors, maternal characteristics, obstetric and neonatal outcomes and maternal complications in patients with severe preeclampsia versus patients without severe preeclampsia. Hence, 235 cases and 470 controls were evaluated and followed in our study. We described a set of variables related to the development of severe preeclampsia, including maternal age > 35 years (69.8%), gestational (26.8%) or chronic arterial hypertension (18.3%), obesity (22.6%), use of assisted reproduction techniques (12.3%), prior history of preeclampsia (10.2%) and chronic kidney disease (7.7%) All patients had severe hypertension (>160 mmHg) and some of them presented with additional complications, such as acute renal failure (51 cases), HELLP syndrome (22 cases), eclampsia (9 cases) and acute cerebrovascular accidents (3 cases). No case of maternal death was recorded, although the SP group had a higher cesarean section rate than the control group (60% vs. 20.9%) (p < 0.001), and there was a notably higher perinatal morbidity and mortality in these patients, who had a prematurity rate of 58.3% (p < 0.001) and 14 perinatal deaths, compared to 1 in the control group. Overall, our study recognized a series of factors related to the development of SP and related complications, which may be of great aid for improving the clinical management of this condition.
PB MDPI
SN 1660-4601
YR 2021
FD 2021-11-10
LK https://hdl.handle.net/20.500.14352/5061
UL https://hdl.handle.net/20.500.14352/5061
LA eng
NO Unión Europea
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
NO Halekulani S.L.
DS Docta Complutense
RD 2 may 2024