RT Journal Article
T1 Proanthocyanidins Block Aldosterone-Dependent Upregulation of Cardiac Gamma Enac and Nedd4–2 Inactivation Via Sgk1
A1 Galiana, Adrián
A1 Olivares Álvaro, Elena
A1 Klett Mingo, Mercedes
A1 Ruiz Roso, María Belén
A1 Heras Jiménez, Natalia De Las
A1 Fuller, Peter J.
A1 Lahera Julia, Vicente
A1 Martín Fernández, Beatriz
AB Aldosterone plays a central role in the development of cardiac pathological states involving ion transport imbalances, especially sodium transport. We have previously demonstrated a cardioprotective effect of proanthocyanidins in aldosterone-treated rats. Our objective was to investigate for the first time, the effect of proanthocyanidins on serum and glucocorticoid regulated kinase type 1 (SGK1), epithelial Na + channel (γ-ENac), neuronal precursor cells expressed developmentally down-regulated 4–2 (Nedd4–2) and phosphoNedd4–2 protein expression in the hearts of aldosterone-treated rats. Male Wistar rats received aldosterone (1 mg/Kg/day) + 1% NaCl for 3 weeks. Half of the animals in each group were simultaneously treated with the proanthocyanidins-rich extract (80% w/w) (PRO80, 5 mg/Kg/day). Hypertension and diastolic dysfunction induced by aldosterone were abolished by treatment with PRO80. Expression of fibrotic, inflammatory and oxidative mediators were increased by aldosterone-salt administration and blunted by PRO80. Antioxidant capacity was improved by PRO80. The up-regulated aldosterone mediator SGK-1, ENaC and p-Nedd4–2/Total Nedd4–2 ratio were blocked by PRO80. PRO80 blunted aldosterone-mineralocorticoid mediated up-regulation of ENaC provides new mechanistic insight of the beneficial effect of proanthocyanidins preventing the cardiac alterations induced by aldosterone excess.
PB Elsevier
SN 0955-2863
YR 2016
FD 2016-08
LK https://hdl.handle.net/20.500.14352/132065
UL https://hdl.handle.net/20.500.14352/132065
LA eng
NO Galiana-Simal A, Olivares-Álvaro E, Klett-Mingo M, Ruiz-Roso MB, Ballesteros S, de Las Heras N, Fuller PJ, Lahera V, Martín-Fernández B. Proanthocyanidins block aldosterone-dependent up-regulation of cardiac gamma ENaC and Nedd4-2 inactivation via SGK1. J Nutr Biochem. 2016 Nov;37:13-19. doi: 10.1016/j.jnutbio.2016.07.012. Epub 2016 Aug 14. PMID: 27592201.
DS Docta Complutense
RD 25 feb 2026