RT Journal Article
T1 Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes
A1 Rancán, Lisa
A1 Puig, Angela
A1 Balibrea, José M.
A1 Paredes Royano, Sergio Damián
A1 García Martín, M. Cruz
A1 Jiménez Roldán, Luis
A1 Fernández-Tresguerres Hernández, Jesús Ángel
A1 Vara Ameigeiras, Elena María
AB Epidemiological data suggest protective effects of oestrogen and phytoestrogen on lung tissue. This study aimed to elucidate the role of 17-β-oestradiol and phytoestrogen in age-related inhibition of surfactant synthesis and oxidative stress in rat type II pneumocytes. Forty male and 66 female Wistar rats were used. Female rats were randomly kept intact or ovariectomized at age 12 months. At age 22 months, ovariectomized rats received 17-β-oestradiol, soy extract, or no treatment. Oxidative stress markers CO, NO, cGMP and lipid peroxide (LPO), antioxidant enzymes and phosphatidylcholine (PC) were measured in cultured type II pneumocytes isolated at ages 2, 14, 18, 22 and 24 months. Old, male and ovariectomized rats showed significantly higher CO, NO, cGMP and LPO and lower PC content and antioxidant enzymes. 17-β-oestradiol and phytoestrogen significantly reversed these effects. In conclusion, aging and oestrogen deprivation decreased PC synthesis and altered the redox status in type II pneumocytes, which were partially restored by 17-β-oestradiol or soy supplementation.
PB Taylor and Francis
SN 0963-7486
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/114467
UL https://hdl.handle.net/20.500.14352/114467
LA eng
NO Rancan L, Puig A, Balibrea JM, Paredes SD, García C, Jiménez L, Fernández-Tresguerres JA, Vara E. Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes. Int J Food Sci Nutr. 2021 Feb;72(1):26-36. doi: 10.1080/09637486.2020.1757044
DS Docta Complutense
RD 10 abr 2025