RT Journal Article T1 Effectiveness of disinfectants used in cooling towers against Legionella pneumophila A1 García Esteban, María Teresa A1 Pelaz, Carmen AB Background: Legionella persists in man-made aquatic installations despite preventive treatments. More information about disinfectants could improve the effectiveness of treatments. This study tests the susceptibility of Legionella pneumophila serogroup (sg) 1 against 8 disinfectants used in cooling tower treatments. Methods: We determined the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and bactericidal effect of sodium hypochlorite (A), hydrogen peroxide with silver nitrate (B), didecyldimethylammonium chloride (C), benzalkonium chloride (D), tributyltetradecylphosphonium chloride (E), tetrahydroxymethylphosphonium sulfide (F), 2,2-dibromonitropropionamide (G) and chloromethylisothiazolone (H) against 28 L. pneumophila sg 1 isolates. Results: MIC and MBC values were equivalent. Bacteria are less susceptible to disinfectants F, B, D and A than to H, E, C and G. All disinfectants induced a bactericidal effect. The effect rate is dose dependent for G, H, F and B; the effect is fast for the rest of disinfectants at any concentration. The bactericidal activity of disinfectants A, G and F depends on the susceptibility test used. Conclusions: All disinfectants have bactericidal activity against L. pneumophila sg 1 at concentrations used in cooling tower treatments. Results depend on the assay for some products. PB Karger SN 0009-3157 YR 2008 FD 2008-02-26 LK https://hdl.handle.net/20.500.14352/125470 UL https://hdl.handle.net/20.500.14352/125470 LA eng NO García, & Pelaz. (2008). Effectiveness of disinfectants used in cooling towers against Legionella pneumophila. Chemotherapy, 54(2), 107-116. https://doi.org/10.1159/000118662 DS Docta Complutense RD 22 ene 2026