RT Journal Article
T1 Telomere Length and Telomerase Activity in Subcutaneous and Visceral Adipose Tissues from Obese and Non-Obese Patients with and without Colorectal Cancer
A1 García Martínez, Sergio
A1 González Gamo, Daniel
A1 Tesolato, Sofía Elena
A1 Barabash Bustelo, Ana
A1 De La-Serna Esteban, Sofía Cristina
A1 Domínguez Serrano, María Inmaculada
A1 Dziakova, Jana
A1 Rivera, Daniel
A1 Torres García, Antonio José
A1 Iniesta Serrano, María Pilar
A2 Luis M. Montuenga, 
AB To investigate the molecular mechanisms that link obesity and colorectal cancer (CRC), we analyzed parameters related to telomere function in subcutaneous and visceral adipose tissues (SAT and VAT), including subjects with and without CRC, who were classified according to their body mass index (BMI). Adipose tissues were obtained from 147 patients who had undergone surgery. A total of 66 cases corresponded to CRC patients, and 81 subjects were not affected by cancer. Relative telomere length was established by qPCR, and telomerase activity was determined by a method based on the telomeric repeat amplification protocol. Our results indicated longer telomeres in patients affected by CRC, both in SAT and VAT, when compared to the group of subjects without CRC. Tumor local invasion was associated with telomere length (TL) in SAT. Considering the BMI values, significant differences were found in the TL of both adipose tissues between subjects affected by CRC and those without cancer. Overweight subjects showed the greatest differences, with longer telomeres in the group of CRC patients, and a higher number of cases with telomerase reactivation in the VAT of subjects without cancer. In conclusion, parameters related to telomere function in adipose tissue could be considered as potential biomarkers in the evaluation of CRC and obesity.
PB MDPI
SN 2072-6694
YR 2022
FD 2022-12-31
LK https://hdl.handle.net/20.500.14352/92001
UL https://hdl.handle.net/20.500.14352/92001
LA eng
NO García-Martínez, S.; González-Gamo, D.; Tesolato, S.E.; Barabash, A.; de la Serna, S.C.; Domínguez-Serrano, I.; Dziakova, J.; Rivera, D.; Torres, A.J.; Iniesta, P. Telomere Length and Telomerase Activity in Subcutaneous and Visceral Adipose Tissues from Obese and Non-Obese Patients with and without Colorectal Cancer. Cancers 2023, 15, 273. https://doi.org/ 10.3390/cancers15010273
NO Carlos III Institute of Health (Ministerio de Economía y Competitividad), Spain
NO European Union through the European Regional Development Fund (ERDF), ‘A way to make Europe.’
DS Docta Complutense
RD 21 ago 2024