RT Journal Article
T1 Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints
A1 Bajo Bretón, Ricardo
A1 Castellanos, Nazareth P.
A1 López García, María Eugenia
A1 Ruiz Sánchez de León, José María
A1 Montejo, Pedro
A1 Montenegro Peña, María Mercedes
A1 Llanero Luque, Marcos
A1 Gil Gregorio, Pedro
A1 Yubero Pancorbo, Raquel
A1 Baykova, Evgenia
A1 Paul Lapedriza, Nuria Ascensión
A1 Aurtenetxe, Sara
A1 Pozo, Francisco del
A1 Maestu Unturbe, Fernando
AB It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.
PB Springer Nature
SN 0161-9152
YR 2011
FD 2011-04-06
LK https://hdl.handle.net/20.500.14352/112452
UL https://hdl.handle.net/20.500.14352/112452
LA eng
NO Bajo, R., Castellanos, N.P., López, M.E., Ruiz-Sánchez de León, J.M., Montejo Carrasco, P., Montenegro Peña, M., Llanero Luque, M., Gil, P., Yubero, R., Baykova, E., Paul Lapedriza, N., Aurtenetxe, S., del Pozo, F. y Maestu Unturbe, F. (2012). Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints. Age, 34(2), 497-506.
NO Erratum inCorrection to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints.Bajo R, Castellanos NP, López ME, Ruiz-Sanchez de Leon JM, Montejo P, Montenegro M, Llanero M, Gil P, Yubero R, Baykova E, Paul N, Aurtenetxe S, Del Pozo F, Maestu F. Published in Geroscience, 2022, 44(3), 1887. doi: 10.1007/s11357-022-00543-1.
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 6 abr 2025