RT Journal Article T1 Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes A1 Collado, Rosa A1 Puiggros, Anna A1 López-Guerrero, José Antonio A1 Calasanz, Ma José A1 Larráyoz, Ma José A1 Ivars, David A1 García-Casado, Zaida A1 Abella, Eugènia A1 Orero, Ma Teresa A1 Talavera, Elisabet A1 Oliveira, Ana Carla A1 Hernández-Rivas, Jesús Ma A1 Hernández Sánchez, María A1 Luño, Elisa A1 Valiente, Alberto A1 Grau, Javier A1 Portal, Inmaculada A1 Gardella, Santiago A1 Salgado, Anna Camino A1 Giménez, Ma Teresa A1 Ardanaz, Ma Teresa A1 Campeny, Andrea A1 Hernández, José Julio A1 Álvarez, Sara A1 Espinet, Blanca A1 Carbonell, Félix AB Although i(17q) [i(17q)] is frequently detected in hematological malignancies, few studies have assessed its clinical role in chronic lymphocytic leukemia (CLL). We recruited a cohort of 22 CLL patients with i(17q) and described their biological characteristics, mutational status of the genes TP53 and IGHV and genomic complexity. Furthermore, we analyzed the impact of the type of cytogenetic anomaly bearing the TP53 defect on the outcome of CLL patients and compared the progression-free survival (PFS) and overall survival (OS) of i(17q) cases with those of a group of 38 CLL patients harboring other 17p aberrations. We detected IGHV somatic hypermutation in all assessed patients, and TP53 mutations were observed in 71.4% of the cases. Patients with i(17q) were more commonly associated with complex karyotypes (CK) and tended to have a poorer OS than patients with other anomalies affecting 17p13 (median OS, 44 vs 120 months, P = 0.084). Regarding chromosomal alterations, significant differences in the median OS were found among groups (P = 0.044). In conclusion, our findings provide new insights regarding i(17q) in CLL and show a subgroup with adverse prognostic features. PB Elsevier Ireland LTD SN 0304-3835 YR 2017 FD 2017-11-28 LK https://hdl.handle.net/20.500.14352/93323 UL https://hdl.handle.net/20.500.14352/93323 LA eng NO Collado R, Puiggros A, López-Guerrero JA, Calasanz MJ, Larráyoz MJ, Ivars D, et al. Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes. Cancer Letters 2017;409:42–8. https://doi.org/10.1016/j.canlet.2017.08.041. DS Docta Complutense RD 24 ago 2024