RT Journal Article
T1 Δ 9 ‐Tetrahydrocannabinol promotes functional remyelination in the mouse brain
A1 Aguado, Tania
A1 Huerga Gómez, Alba
A1 Sánchez de la Torre, Aníbal
A1 Resel, Eva
A1 Chara, Juan Carlos
A1 Matute, Carlos
A1 Mato, Susana
A1 Galve Roperh, Ismael
A1 Guzmán Pastor, Manuel
A1 Palazuelos Diego, Javier
AB Background and purpose: Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional recovery. Δ9 -Tetrahydrocannabinol (THC), the most prominent active constituent of the hemp plant Cannabis sativa, confers neuroprotection in animal models of demyelination. However, the possible effect of THC on myelin repair has never been studied. Experimental approach: By using oligodendroglia-specific reporter mouse lines in combination with two models of toxin-induced demyelination, we analysed the effect of THC on the processes of oligodendrocyte regeneration and functional remyelination. Key results: We show that THC administration enhanced oligodendrocyte regeneration, white matter remyelination and motor function recovery. THC also promoted axonal remyelination in organotypic cerebellar cultures. THC remyelinating action relied on the induction of oligodendrocyte precursor differentiation upon cell cycle exit and via CB1 cannabinoid receptor activation. Conclusions and implications: Overall, our study identifies THC administration as a promising pharmacological strategy aimed to promote functional CNS remyelination in demyelinating disorders.
PB Wiley
SN 0007-1188
YR 2021
FD 2021-07-03
LK https://hdl.handle.net/20.500.14352/4700
UL https://hdl.handle.net/20.500.14352/4700
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER)
NO Gobierno Vasco
NO Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques, ARSEP Foundation
NO National Institute of Health (NIH)
DS Docta Complutense
RD 6 abr 2025