TY - JOUR AU - Escudero García-Calderón, José Antonio AU - Rodríguez-Beltrán, Jerónimo AU - Hernández-Beltrán, J. Carlos R. AU - De la Fuente, Javier AU - Fuentes-Hernández, Ayari AU - MacLean, R. Craig AU - Peña-Miller, Rafael AU - San Millan, Álvaro PY - 2018 DO - 10.1038/s41559-018-0529-z SN - 2397-334X UR - https://hdl.handle.net/20.500.14352/94237 T2 - Nature Ecology and Evolution AB - Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the... LA - eng M2 - 873 TI - Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation TY - journal article VL - 2 ER -