RT Journal Article
T1 Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
A1 Castillo, Rafael R.
A1 Lozano Borregón, Daniel
A1 Vallet Regí, María Dulce Nombre
AB ABSTRACT: Despite encapsulation of drugs claim to improvethe therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targeted devices, aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, there has been designed a two-drug delivery system with dual cell-organelle targeting based on Mesoporous Silica Nanoparticles, known to be able to host drugs within their pores. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug delivery nanodevices against difficult-to-treat cancers.
PB American Chemical Society
SN 1043-1802
YR 2018
FD 2018-10-01
LK https://hdl.handle.net/20.500.14352/12254
UL https://hdl.handle.net/20.500.14352/12254
LA eng
NO RESEARCHER ID L-2854-2014 (Rafael Castillo Romero)ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO European Research Council
NO Ministerio de Economía y Competitividad (MINECO)
NO FONDO EUROPEO DE DESARROLLO REGIONAL (FEDER)
DS Docta Complutense
RD 10 abr 2025